Results 211 to 220 of about 274,463 (252)

Dynamics and master transcription factors dependence of intestinal super-enhancers during differentiation and oncogenesis. [PDF]

Nucleic Acids Res
Fang W, Huang S, Xiao R, Wei G, Zhang M, Qiu X, Zou L, Verzi MP, Wang Y, Chen L.   +9 more
europepmc   +1 more source

Organ-on-chip (OoC) and nano-biomaterials: next generation of precision oral and dental healthcare research. [PDF]

J Nanobiotechnology
Wadan AS, El-Gemaie DSA, Bayoumi AM, Zein MM, El Sattar Ahmed MA, El-Khawaga AM, Nagy MM.   +6 more
europepmc   +1 more source

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Microfluidic Systems and Organ (Human) on a Chip

2021
In the previous chapters we learned how cells are cultivated in 3D and how the surrounding gel matrix is optimized. However, to achieve even higher physiologically relevant cell culture conditions, the surrounding environment must be controlled by emerging microfluidic systems.
Bahnemann, Janina, Enders, Anton, Winkler, Steffen   +2 more
openaire   +2 more sources

Modeling mucus physiology and pathophysiology in human organs-on-chips

Advanced Drug Delivery Reviews, 2022
The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic relationships with commensal microbiome while protecting against potentially injurious environmental chemicals, toxins, and pathogens, and disruption of this layer can contribute to disease development.
Zohreh, Izadifar, Alexandra, Sontheimer-Phelps, Bob A, Lubamba, Haiqing, Bai, Cicely, Fadel, Anna, Stejskalova, Alican, Ozkan, Queeny, Dasgupta, Amir, Bein, Abidemi, Junaid, Aakanksha, Gulati, Gautam, Mahajan, Seongmin, Kim, Nina T, LoGrande, Arash, Naziripour, Donald E, Ingber   +15 more
openaire   +2 more sources

Microfabrication of human organs-on-chips

Nature Protocols, 2013
'Organs-on-chips' are microengineered biomimetic systems containing microfluidic channels lined by living human cells, which replicate key functional units of living organs to reconstitute integrated human organ-level pathophysiology in vitro. These microdevices can be used to test efficacy and toxicity of drugs and chemicals, and to create in vitro ...
Dongeun, Huh, Hyun Jung, Kim, Jacob P, Fraser, Daniel E, Shea, Mohammed, Khan, Anthony, Bahinski, Geraldine A, Hamilton, Donald E, Ingber   +7 more
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Humans on a chip

Science, 2020
Physiology Organ chips are devices in which epithelial and/or stromal cells are grown in a chamber filled with medium connected by a porous matrix-like membrane to another chamber lined with endothelial cells and containing a blood substitute. Depending on the cell types used and the contents of the blood substitute and medium, these chips can model ...
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Modelling cancer in microfluidic human organs-on-chips

Nature Reviews Cancer, 2019
One of the problems that has slowed the development and approval of new anticancer therapies is the lack of preclinical models that can be used to identify key molecular, cellular and biophysical features of human cancer progression. This is because most in vitro cancer models fail to faithfully recapitulate the local tissue and organ microenvironment ...
Alexandra Sontheimer-Phelps, Bryan A. Hassell, Donald E. Ingber   +2 more
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Single Cell Grid Networks of Human Astrocytes On Chip

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), 2019
In this paper, we demonstrate, for the first time, how we can pattern grid networks of human hNT astrocytes on parylene-C/SiO2 substrates down to the single cell level. We demonstrate that the functionality of the astrocyte networks by calcium release on the introduction of ATP and show that this is similar to that of a control sample.
Si Li, M. Cather Simpson, E. Scott Graham, Charles P. Unsworth   +3 more
openaire   +1 more source