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Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment
Trends in Food Science & Technology, 2016Equipment and device qualification and test assay validation in the field of tissue engineered human organs for substance assessment remain formidable tasks with only a few successful examples so far. The hurdles seem to increase with the growing complexity of the biological systems, emulated by the respective models.
Sofia P, Rebelo +5 more
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Development of Biomimetic Human Lung Alveolus Chip
2023The potential of physiologically relevant in vitro cell culture models for studying physiological and pathophysiological phenomena has been widely recognized as replacements for animal and conventional in vitro models. To create models that accurately replicate the structure and function of tissues and organs, it is essential to comprehend the ...
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The Ultimate Gene Gizmo: Humanity on a Chip
Science, 2003Commercial genomics reached a landmark last week. Three companies--Affymetrix, Agilent Technologies, and NimbleGen Systems--are now offering arrays covering all known human genes.
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Measurement of naproxen in human plasma by chip‐based immunoaffinity capillary electrophoresis
Biomedical Chromatography, 2006AbstractAn electrokinetic immunoassay performed in a chip‐based capillary electrophoresis system is described for the rapid measurement of naproxen in human plasma. The system employs a fluorescently labeled antibody to capture and detect the analyte of interest within a 5 min total assay time with an LOD of 0.025 µg/mL and a saturation level of 450 µg/
Terry M, Phillips, Edward F, Wellner
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From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications
ACS SensorsOrgan-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology is also facing notable challenges, such as the lack of vascularization, the development of multiorgan-on-a-chip ...
Yuxi Wang
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Application of the Human Intestinal Tract Chip to the non-human primate gut microbiota
Beneficial Microbes, 2015The human intestinal microbiota is responsible for various health-related functions, and its diversity can be readily mapped with the 16S ribosomal RNA targeting Human Intestinal Tract (HIT) Chip. Here we characterise distal gut samples from chimpanzees, gorillas and marmosets, and compare them with human gut samples.
Bello Gonzalez, T.D.G. +6 more
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Biologically Inspired, iterative engineering of a Human Lymphoid Follicle Chip
The Journal of Immunology, 2018Abstract Organs Chips are microengineered, three-dimensional (3D) in vitro models that simulate organ-level pathophysiology and therapeutic responses with high fidelity. Here, we report the development of an in vitro model of lymphoid follicles seen in germinal centers and sites of chronic inflammation.
Girija Goyal +3 more
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Advances in the construction of human organs-on-chips
Chinese Science Bulletin, 2023Yi Zeng, Zhongze Gu
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Microfluidic based human-on-a-chip: A revolutionary technology in scientific research
Trends in Food Science and Technology, 2021S Syama, P V Mohanan
exaly