Results 221 to 230 of about 263,329 (257)

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Synergistic Combination of Additive One- and Two-Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis-on-a-Chip Systems. [PDF]

Eng Life Sci
Sokoliuk D, Bouhaya R, Haeger P, Godthardt K, Fetting D, Spiecker L, Spiecker H, Rockenbach A, Rothe H, Liefeith K, Heinrich D.   +10 more
europepmc   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation. [PDF]

Science
Agarwal G, Antoszewski M, Xie X, Pershad Y, Arora UP, Poon CL, Lyu P, Lee AJ, Guo CJ, Ye T, Norford LB, Neehus AL, Della Volpe L, Wahlster L, Ranasinghe D, Ho TC, Barlowe TS, Chow A, Schurer A, Taggart J, Durham BH, Abdel-Wahab O, McGraw KL, Allan JM, Soldatov R, Bick AG, Kharas MG, Sankaran VG.   +27 more
europepmc   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease. [PDF]

Eur Heart J
von Scheidt M, Adkar SS, Krefting J, Hoermann G, Meggendorfer M, Bauer S, Mitchell S, Pugach I, Friess C, Ma A, Hao K, Steigerwald S, Wahle M, Kessler T, Schwab M, Voll F, Mokry M, Sofokleous C, Palm KCA, Bongiovanni D, Fleig J, Oldenbuettel L, Chen Z, Hecker JS, Bassermann F, Maegdefessel L, Graw M, Ruusalepp A, Hilgendorf I, Leuschner F, Sager HB, Heimlich JB, Koenig W, Cremer S, Leistner DM, Abplanalp WT, Dimmeler S, Zeiher AM, van der Laan SW, Pasterkamp G, Braun C, Jaiswal S, Kovacic JC, Kern W, Haferlach C, Mann M, Cassese S, Kastrati A, Haferlach T, Leeper NJ, Björkegren JLM, Schunkert H.   +51 more
europepmc   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Application and prospects of lung organ-on-a-chip in the development of new drugs. [PDF]

Biomed Eng Online
Su J, Qiu J, Meng J, Gong Y, Xu Y, Han J.   +5 more
europepmc   +1 more source