Results 141 to 150 of about 2,199,898 (317)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Desk study of the possible impact of fisheries and other human activities on the marine environment in Mauritania. An exploration

, 2008
Wageningen IMARES has been contracted by Dutch Ministry of Agriculture, Nature and Food Quality with funding from the “BO PPP”-programme to make an inventory of existing and expected future human activities in that part of the Eastern Atlantic Ocean that
Wal, J.T., van der, Goudswaard, P.C.
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The Activities of the Niger Delta Militancy: The Roadmap to Development

, 2018
This research work investigates the activities of the Niger Delta militants and how it affects the developmental strides of the Nigerian economy We use primary data with a target population of students oil company workers civil servants public ...
Past. Dr. Abomaye-Nimenibo, Williams Aminadokiari Samuel   +1 more
core  

Preferred human resource development activities and their functions: Differences in perspective between managers and employees

, 2019
This exploratory study uses the learning‐network theory as a framework to investigate how managers and employees differ in their preference for the human resource development (HRD) activities of employees and in the functions they attribute to HRD.
Irina Lilova, Poell, Robert Frans, Rob F. Poell, Poell, Robert Frans; id_orcid, Lilova, Irina   +4 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Spatial Relationship Between Two Sympatric Pheasant Species and Various Human Disturbance Activities

Establishing and managing nature reserves to mitigate wildlife habitat loss and fragmentation is challenging, particularly in the face of increasing human activity.
Meisheng Zhou, Baowei Zhang, Yinfan Cai, Liling Ji, Dapeng Pang, Faguang Pu, Yuting Lu, Lanrong Wang, Yang Cheng   +8 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Activities of Sea Robbers and Its Implication on Water Transportation: Experience from Niger Delta Region of Nigeria

, 2020
The main thrust of this study was to examine activities of Sea Robbers and its implication on water transportation in Niger Delta Region of Nigeria A multi-stage sampling technique was employed to select respondents from three littoral states in the ...
Adongoi, Toakodi, Azibasuam Adioni-Arogo, Ifeanyichukwu, Otodo   +3 more
core