Results 81 to 90 of about 9,289,046 (328)

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. [PDF]

, 2019
Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal stability through increased
Brody, Matthew J, Correll, Robert N, Karch, Jason, Khalil, Hadi, Maillet, Marjorie, Molkentin, Jeffery D, Ross, Robert S, Sargent, Michelle A, Schips, Tobias G, Tjondrokoesoemo, Andoria, Vanhoutte, Davy, Vo, Alexander   +11 more
core   +3 more sources

The role of human adenoviruses type 41 in acute diarrheal disease in Minas Gerais after rotavirus vaccination

Brazilian Journal of Microbiology, 2016
Human adenovirus species F (HAdV-F) type 40 and 41 are commonly associated with acute diarrheal disease (ADD) across the world. Despite being the largest state in southeastern Brazil and having the second largest number of inhabitants, there is no ...
Thaís Aparecida Vieira Reis, A. Assis, D. A. do Valle, Vívian Honorato Barletta, Iná Pires de Carvalho, T. Rose, S. A. Portes, J. Leite, M. L. da Rosa e Silva   +8 more
semanticscholar   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Adenovirus-Associated Influenza-Like Illness among College Students, Pennsylvania, USA

Emerging Infectious Diseases, 2018
Among students with influenza-like illness at a Pennsylvania college student health center during 2016–2017, 44 (15%) of 288 with respiratory specimens tested positive for human adenovirus (HAdV).
Holly M. Biggs, Xiaoyan Lu, Lisa Dettinger, Senthilkumar Sakthivel, John T. Watson, Sameh W. Boktor   +5 more
doaj   +1 more source

Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]

, 2008
The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Ahmed, Altschul, Andersson, Beatrice Menz, Beier, Bennett, Bruder, Bryson, Burgert, Burgert, Burgert, Burgert, Burgert, Cole, Cox, Deryckere, Edgar, Elsing, Feuerbach, Flomenberg, Flomenberg, Fox, Gabathuler, Gewurz, Ginsberg, Hans-Gerhard Burgert, Hermiston, Hilgendorf, Jackson, Jackson, Jefferies, Katja Koebernick, Kornfeld, Krogh, Kurowski, Köhler, Körner, Lichtenstein, Liu, Liu, Lodoen, Mans, Martina Sester, McNees, McSharry, Nilsson, Persson, Pääbo, Pääbo, Pääbo, Ralf Schmid, Rawle, Rost, Rost, Rost, Sester, Sester, Tanaka, The_UniProt_Consortium, von Herrath, Windheim, Wold, Wold   +62 more
core   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

In vitro and in vivo tropism and biodistribution of recombinant simian adenovirus type 25

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Recombinant adenoviruses are widely used in the development of vaccines for a variety of infectious diseases. Despite numerous clinical studies, only a few types of human (types 5 and 26) and simian (isolate Y25) adenoviruses are currently ...
Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg   +11 more
doaj   +1 more source

Detection and Molecular Typing of Human Adenoviruses Associated with Respiratory Illnesses in Kerala.

Japanese journal of infectious diseases (Print), 2016
Adenoviruses are responsible for approximately 5-10% of acute respiratory infections globally. However, there are a limited number of reports on the types of circulating respiratory human adenoviruses (HAdV) in India.
Asia Devi Thounaojam, Anukumar Balakrishnan, A. Mun   +2 more
semanticscholar   +1 more source