Results 131 to 140 of about 2,152,983 (311)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Adult literacy and numeracy, social capital, learner identities and self-confidence
, 2007 This paper explores the interconnections between literacies learning, self-confidence, identity as a learner and social capital. It draws from a two-phased study of over 600 literacy and numeracy learners in Scotland that examined various aspects of ...
Tett, Lyn, Maclachlan, Kathy
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Molecular Fate Determinants in Embryonic and Adult Neural Stem Cells [PDF]
, 2005 The molecular signals specifying neuronal, glial or multipotent precursors in the developing and adult central nervous system (CNS) are largely unknown. Radial glial cells have recently been discovered as major precursor population generating neurons or ...
Hack, M.A., Hack, Michael Anton
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 2021 Adult Human Fibroblasts Cultured on 3D Silk Fibroin Nonwovens Release Exosomes Strongly Stimulating ...
Hu, P +4 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
, 2020 This study examined the roles of adult education programmes in poverty alleviation in Okrika and Port Harcourt City Local Government Areas of Rivers State 3 research questions and 3 research objectives guided the study 3 hypotheses were also tested at ...
Dr. Doreen Kobani +1 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Regionalization of adult neurogenesis
, 2009 The vast majority of neurons in the murine brain are generated during embryonic neurogenesis. However, at least two neurogenic niches continue to produce specific types of neurons throughout life. The adult dentate gyrus harbours stem cells that generate
Brill, Monika
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