Results 1 to 10 of about 173,229 (189)

Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia [PDF]

Emerging Infectious Diseases, 2023
We report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera, Tihitina Mamecha, Ebise Abose, Belachew Bokicho, Agune Ashole, Tesfahun Bishaw, Abinet Mariyo, Buzayehu Bogale, Haileyesus Terefe, Henok Tadesse, Mahlet Belachew, Hailemariam Difabachew, Araya Eukubay, Solomon Kinde, Abraham Ali, Feyesa Regasa, Fikre Seife, Zeyede Kebede, Mesfin Wossen, Getachew Tollera, Mesay Hailu, Nigus Manaye, Nick Van Reet, Gerardo Priotto, Johan van Griensven, Myrthe Pareyn, Geremew Tasew   +26 more
doaj   +3 more sources

Epidemiology of human African trypanosomiasis

Clinical Epidemiology, 2014
Jose R Franco,1 Pere P Simarro,1 Abdoulaye Diarra,2 Jean G Jannin1 1World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland; 2World Health Organization, Inter Country Support ...
Franco JR, Simarro PP, Diarra A, Jannin JG   +3 more
doaj   +6 more sources

Human African trypanosomiasis

The Lancet, 2010
Epidemiology, diagnosis, and treatment of one of the world’s most neglected ...
R. Brun, J. Blum, F. Chappuis, C. Burri
semanticscholar   +6 more sources

Human African trypanosomiasis cases diagnosed in non-endemic countries (2011-2020). [PDF]

PLoS Negl Trop Dis, 2022
Background Sleeping sickness, or human African trypanosomiasis (HAT), is transmitted by tsetse flies in endemic foci in sub-Saharan Africa. Because of international travel and population movements, cases are also occasionally diagnosed in non-endemic ...
Franco JR, Cecchi G, Priotto G, Paone M, Kadima Ebeja A, Simarro PP, Diarra A, Sankara D, Zhao W, Dagne DA.   +9 more
europepmc   +2 more sources

Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership. [PDF]

Diseases, 2022
After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre ...
Bernhard S, Kaiser M, Burri C, Mäser P.
europepmc   +2 more sources

Transforming the chemotherapy of human African trypanosomiasis. [PDF]

Clin Microbiol Rev
SUMMARY Prior to 2019, when the orally available drug fexinidazole began its clinical use, the treatment of human African trypanosomiasis (HAT) was complex and unsatisfactory for many reasons.
Barrett MP.
europepmc   +2 more sources

SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis. [PDF]

EBioMedicine, 2022
Elimination of Human African Trypanosomiasis (HAT) requires highly specific and sensitive tools for both diagnostic at point of care and epidemiological surveys.
Sima N, Dujeancourt-Henry A, Perlaza BL, Ungeheuer MN, Rotureau B, Glover L.   +5 more
europepmc   +2 more sources

Gambiense human African trypanosomiasis: the bumpy road to elimination. [PDF]

Curr Opin Infect Dis, 2022
Purpose of review Gambiense human African trypanosomiasis (gHAT), a disease that has killed hundreds of thousands as recently as the 1990s, could be on the verge of elimination or even eradication.
Hasker E, Hope A, Bottieau E.
europepmc   +2 more sources

The elimination of human African trypanosomiasis: Monitoring progress towards the 2021-2030 WHO road map targets. [PDF]

PLoS Negl Trop Dis
Background Human African trypanosomiasis (HAT) is a neglected tropical disease that usually occurs in rural areas in sub-Saharan Africa. It caused devastating epidemics during the 20th century.
Franco JR, Priotto G, Paone M, Cecchi G, Ebeja AK, Simarro PP, Sankara D, Metwally SBA, Argaw DD.   +8 more
europepmc   +2 more sources

Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program. [PDF]

Am J Trop Med Hyg, 2022
. In this article, the authors show the strategy used to streamline the introduction of fexinidazole, the first all oral treatment of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense.
Valverde Mordt O, Tarral A, Strub-Wourgaft N.   +2 more
europepmc   +2 more sources