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A Genome-Wide Association Study Reveals Novel Genetic Markers Associated with Human African Trypanosomiasis

Mulindwa J, Kimuda MP, Noyes H, Ilboudo H, Koffi M, Ahouty B, Nyangiri O, Cooper A, Clucas C, Nambala P, Musaya J, Ngoyi D́M, Karume K, Fataki O, Simo G, Ofon E, Enyaru J, Nerima B, Tait A, Marcello L, Chisi J, Kabore J, Kabore JW, Kamoto K, Simuunza M, Alibu VP, Jamonneau V, Camera M, Camara M, Bucheton B, Hertz-Fowler C, Macleod A, Matovu E, TrypanoGEN Research Group as members of The H3Africa Consortium.   +33 more
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Human African trypanosomiasis

Lancet, The
Human African trypanosomiasis or sleeping sickness is caused by infection with Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense parasites, which are transmitted by tsetse flies in sub-Saharan Africa. Control of human African trypanosomiasis is based on case detection, treatment, and vector control.
Veerle Lejon, Andreas K Lindner, JOSÉ R Franco   +2 more
exaly   +6 more sources

Human African Trypanosomiasis

Infectious Disease Clinics of North America, 2012
Abstract Human African trypanosomiasis (sleeping sickness) is caused by subspecies of the protozoan parasite Trypanosoma brucei. The disease is restricted to tropical Africa where it is transmitted by the bite of infected tsetse flies (Glossina spp.).
Johannes Blum
exaly   +4 more sources

Treatment perspectives for human African trypanosomiasis

Fundamental and Clinical Pharmacology, 2003
AbstractHuman African trypanosomiasis (HAT), or sleeping sickness, is currently on the rise. HAT develops in two stages, the first involving the hemolymphatic system, and the second, the neurological system. Left untreated, HAT is invariably fatal. There have been no therapeutic advances in more than 40 years.
Bernard Bouteille, Sylvie Bisser, Michel Dumas   +2 more
exaly   +3 more sources

Human African Trypanosomiasis

2003
Human African trypanosomiasis (HAT) is caused by infestation with a flagellate protozoan, the trypanosome which is inoculated by the bite of the tsetse fly Glossina. The particular ecological conditions of parasites and vectors are such that the disease is only found in the intertropical regions of Africa.
M, Dumas, B, Bouteille
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Conflict and human African trypanosomiasis

Social Science & Medicine, 2011
Human African Trypanosomiasis (HAT) has reemerged in sub-Saharan Africa as a disease of major public health importance. The success of HAT elimination in sub-Saharan Africa is subject to the feasibility of controlling, eliminating, or mitigating the determinants of incidence in affected countries.
Lea, Berrang-Ford, Jamie, Lundine, Sebastien, Breau   +2 more
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Human African trypanosomiasis: MRI

Neuroradiology, 1997
We report a case of human African trypanosomiasis caused by Trypanosoma brucei rhodesiense. After the febrile period of parasite dissemination, the patient had meningeal involvement but normal CT. MRI showed the appearances of meningitis. After two periods of arsenical treatment, a severe encephalopathy occurred suggesting post-therapeutic reactive ...
P, Sabbah, C, Brosset, P, Imbert, G, Bonardel, P, Jeandel, J F, Briant   +5 more
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Chemotherapy of Human African Trypanosomiasis

Current Pharmaceutical Design, 2002
Human African trypanosomiasis or sleeping sickness is resurgent [1,2]. The disease is caused by subspecies of the parasitic haemoflagellate, Trypanosoma brucei. Infection starts with the bite of an infected tsetse fly (Glossina spp.). Parasites move from the site of infection to the draining lymphatic vessels and blood stream. The parasites proliferate
Richard J S, Burchmore, Patrick O J, Ogbunude, Bertin, Enanga, Michael P, Barrett   +3 more
openaire   +2 more sources