A Selective Phenyl Azo Acetate Substrate for Enhanced Carbonic Anhydrase Functional Analysis
Analytical Science Advances, Volume 7, Issue 1, June 2026.ABSTRACT Carbon dioxide (CO2) sequestration is a key strategy for mitigating climate change, and biocatalytic approaches offer sustainable, cost‐effective alternatives to chemical and physical methods. Carbonic anhydrases (CAs) efficiently catalyse the reversible hydration of CO2 to bicarbonate, yet their large‐scale application is constrained by ...
Justinas Babinskas, Inga Matijošytė
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ProTides for Antiviral Activity Beyond Liver Cells
Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel +5 more
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Comprehensive Physiology, Volume 16, Issue 3, June 2026.Chronic methamphetamine (MA) exposure caused mild, compensated pulmonary hypertension, whereas binge‐and‐crash exposure produced severe PAH with right‐ventricular dysfunction and marked vascular remodeling. Binge‐crash rats showed elevated plasma HMGB1, while in vitro methamphetamine triggered endothelial HMGB1 release that promoted smooth‐muscle ...
Ashok Kumar +4 more
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Expression of the human carboxylesterase 2 enzyme (CES2) in mammalian cells [PDF]
, 2011 Dissertation to obtain a Master Degree in BiotechnologyThe carboxylesterase 2 enzyme (CES2), the main carboxylesterase (CES) expressed in human intestine, has a key role in the metabolism of ester containing xenobiotics including the activation of ...
Cunha, Bárbara Martins Paiva da
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Characterization of carboxylesterases involved in the insecticide resistance of Culex quinquefasciatus from the Caribbean and South America. [PDF]
The organophosphate resistance-associated elevated esterases Estα2, Estβ1 and Estβ2 were purified to homogeneity from larvae of the Cuban Habana strain.
Small, Graham John
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Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡ [PDF]
, 2007 The organophosphorus nerve agents sarin, soman, tabun, and VX exert their toxic effects by inhibiting the action of human acetylcholinesterase, a member of the serine hydrolase superfamily of enzymes.
Redinbo, Matthew +6 more
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International Journal of General Medicine, 2023 Weikun Qu,1,2,* Yalu Yao,1,* Yaqian Liu,1,* HyonSu Jo,1,3 Qianran Zhang,1,* Haidong Zhao1,* 1Department of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian, 116023, People’s Republic of
Qu W +5 more
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Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes [PDF]
, 2018 The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. DLM, CPM and TPM were metabolised by human CYP2B6 and CYP2C19,
A. Kenneth MacLeod +19 more
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The amino acid substitution and some chemical properties of a variant human erythrocyte carbonic anhydrase: Carbonic anhydrase Id Michigan [PDF]
, 1967 Carbonic anhydrase Id Michigan , an electrophoretic variant of human red cell carbonic anhydrase I, was purified from erythrocytes obtained from an individual heterozygous for the trait.
Shows, Thomas B.
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Short Communication Contributions of Arylacetamide Deacetylase and Carboxylesterase 2 to Flutamide Hydrolysis in Human Liver [PDF]
, 2020 : Flutamide, an antiandrogen drug, is widely used for the treatment of prostate cancer. The major metabolic pathways of flutamide are hydroxylation and hydrolysis. The hydrolyzed metabolite, 5-amino-2-nitrobenzotrifluoride (FLU-1), is further metabolized
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