Results 111 to 120 of about 10,733 (194)

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c

Cells
Increased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).
Rajakumar Selvaraj, Jihong Lian, Russell Watts, Randal Nelson, Michael F. Saikali, Carolyn L. Cummins, Richard Lehner   +6 more
doaj   +1 more source

Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients [PDF]

, 2013
Although alpha-fetoprotein (AFP) is currently the major serologic biomarker for hepatocellular carcinoma (HCC), it cannot efficiently distinguish this cancer from other forms of liver disease in early diagnosis due to its low sensitivity. The aim of this
김선아, 이현웅, 김경식, 송시영, 김호근   +4 more
core   +1 more source

Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing

American Journal of Physiology-Cell Physiology, 2012
Cholesteryl ester (CE) hydrolysis is the rate-limiting step in the removal of free cholesterol (FC) from macrophage foam cells, and several enzymes have been identified as intracellular CE hydrolases in human macrophages. We have previously reported the antiatherogenic role of a carboxylesterase [carboxylesterase 1 (CES1)], and the objective of the ...
Bin, Zhao, Jinghua, Bie, Jing, Wang, Stephanie A, Marqueen, Shobha, Ghosh   +4 more
openaire   +3 more sources

Eicosapentaenoic acid inhibits cholesterol efflux pathways from cholesterol-loaded human THP-1 macrophages by reducing the hydrolysis of cholesteryl esters mediated by carboxylesterase 1 [PDF]

International audienceA diet high in n-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) (C20:5 n-3), is cardioprotective. PUFAs integrate into membrane phospholipids, altering membrane protein function.
Noël, Benoît, Slimene, Sana, Paul, Jean-Louis, Abi-Saleh, Nathalie, Vedie, Benoît, Benardeau, Morgane, Rousseau-Ralliard, Delphine, Dakroub, Hani, Cassard, Anne-Marie, Fournier, Natalie, Nowak, Maxime   +10 more
core   +1 more source

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Drug Design, Development and Therapy, 2019
Nora Freyer,1 Fanny Knöspel,1 Georg Damm,2 Selina Greuel,1 Christin Schneider,1 Daniel Seehofer,2 Thomas Stöhr,3 Karl-Uwe Petersen,3 Katrin Zeilinger1 1Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité &ndash ...
Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K   +8 more
doaj  

Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRaf V600E /Pten −/− mice

Cancer & Metabolism
Background Melanoma is a highly aggressive skin cancer with a poor prognosis. The endocannabinoids 2-arachidonoylgylcerol (2-AG) and anandamide have been linked to melanoma progression, though their roles remain unclear.
Veronika Morozova, Daniele Pellegata, Roch-Philippe Charles, Jürg Gertsch   +3 more
doaj   +1 more source

Personalizing treatment using biomarkers to predict the activity of human carboxylesterase 1 [PDF]

, 2015
Personalized medicine is an evolving medical field aiming to customize treatments through genetic profiling, resulting in an improved therapeutic response and minimizing adverse effects.
Heimbürger, Sebastian, Gammltoft, Karen, Henriksen, Beatriche, Niclasen, Laura, Kofod, Lotte   +4 more
core  

Immunogenic Modulations Induced by Prospective Anti-Malarial Herbal Extracts in Murine Model [PDF]

, 2010
Keeping in view the ever increasing problem of drug resistance and affordability of the antimalarial drugs by the poor mass, herbal medicines can become an important and alternative sustainable strategy for malaria treatment.
Sudipta Chakraborty, Sanat Biswas, Sreemayee Sarkar, Suman Mukherjee, Guruprasad Mandal, Niladri Sekhar Bhunia, Dipankar Singha, Chinmoy Karjee, Swapna Chhetri, Shyamal Das Gupta, Sajal Ray, Manoj Das   +11 more
core   +1 more source

Triazine Thiols Decrease Apolipoprotein B Secretion From Hepatocytes Through Inhibition of Human Carboxylesterase 1. [PDF]

Cell Mol Gastroenterol Hepatol
Blaszkiewicz J, Jiang YL, Liu JT, Martinez-Morant C, Dearth T, van Altena C, Lamprecht MP, Kappler C, Lee MH, Bethard JR, Ball LE, Duncan SA.   +11 more
europepmc   +1 more source

Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine [PDF]

Chemistry & Biology, 2003
Bencharit, Sompop, Morton, Christopher L, Hyatt, Janice L, Kuhn, Peter, Danks, Mary K, Potter, Philip M, Redinbo, Matthew R   +6 more
openaire   +1 more source