Results 21 to 30 of about 10,733 (194)

Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma [PDF]

PROTEOMICS, 2009
AbstractTo identify and characterize a serologic glycoprotein biomarker for hepatocellular carcinoma (HCC), multi‐lectin affinity chromatography was used to isolate intracellular N‐linked glycoprotein fractions from five paired non‐tumor and tumor tissues.
Keun, Na, Eun-Young, Lee, Hyoung-Joo, Lee, Kwang-Youl, Kim, Hanna, Lee, Seul-Ki, Jeong, An-Sung, Jeong, Sang Yun, Cho, Sun A, Kim, Si Young, Song, Kyung Sik, Kim, Sung Won, Cho, Hoguen, Kim, Young-Ki, Paik   +13 more
core   +6 more sources

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis. [PDF]

Angew Chem Int Ed Engl
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Okunlola GA, Aleku GA.
europepmc   +3 more sources

Multisite Promiscuity in the Processing of Endogenous Substrates by Human Carboxylesterase 1 [PDF]

Journal of Molecular Biology, 2006
Human carboxylesterase 1 (hCE1) is a drug- and endobiotic-processing serine hydrolase that exhibits relatively broad substrate specificity. It has been implicated in a variety of endogenous cholesterol metabolism pathways including the following apparently disparate reactions: cholesterol ester hydrolysis (CEH), fatty acyl Coenzyme A hydrolysis (FACoAH)
Sompop, Bencharit, Carol C, Edwards, Christopher L, Morton, Escher L, Howard-Williams, Peter, Kuhn, Philip M, Potter, Matthew R, Redinbo   +6 more
openaire   +5 more sources

Nomenclature for alleles of the human carboxylesterase 1 gene [PDF]

Pharmacogenetics and Genomics, 2017
The carboxylesterase 1 gene (CES1) in humans encodes a hydrolase, which is implicated in the metabolism of several commonly used drugs 1. This gene is located on chromosome 16 with a highly homologous pseudogene, CES1P1, in its proximity. A duplicated segment of CES1 replaces most of CES1P1 in some individuals, thus leading to the formation of a hybrid
Rasmussen, Henrik Berg, Madsen, Majbritt B., Hansen, Peter R., Bjerre, Ditte, Ferrero, Laura, Linnet, Kristian, Thomsen, Ragnar, Jürgens, Gesche, Dalhoff, Kim Peder, Stage, Claus, Stefansson, Hreinn, Hankemeier, Thomas, Kaddurah-Daouk, Rima, Brunak, Søren, Taboureau, Olivier, Nzabonimpa, Grace Shema, Jeppesen, Pia, Kaalund-Jørgensen, Kristine, Kristensen, Karl Emil, Pagsberg, Anne Katrine, Plessen, Kerstin Jessica, Hansen, Poul Erik; id_orcid 0000-0003-4751-9910, Werge, Thomas, Dyrborg, Jørgen, Lauritzen, Maj Britt, Hughes, Tim, Lyauk, Yassine Kamal   +26 more
openaire   +4 more sources

Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1) [PDF]

Xenobiotica, 2015
1. Fructus psoraleae (FP) is the dried ripe seeds of Psoralea corylifolia L. (Fabaceae) widely used in Asia, and has been reported to exert important biochemical and pharmacological activities. The adverse effects of FP remain unclear. The present study aims to determine the inhibition of human carboxylesterase 1 (CES1) by FP’s major ingredients ...
Dong-Xue, Sun, Guang-Bo, Ge, Pei-Pei, Dong, Yun-Feng, Cao, Zhi-Wei, Fu, Rui-Xue, Ran, Xue, Wu, Yan-Yan, Zhang, Hui-Ming, Hua, Zhenying, Zhao, Zhong-Ze, Fang   +10 more
openaire   +4 more sources

Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth [PDF]

Journal of Proteome Research, 2020
We previously reported that human carboxylesterase 1 (CES1), a serine esterase containing a unique N-linked glycosyl group at Asn79 (N79 CES1), is a candidate serological marker of hepatocellular carcinoma (HCC). CES1 is normally present at low-to-undetectable levels in normal human plasma, HCC tumors, and major liver cancer cell lines.
Keun Na, Minjoo Kim, Chae-Yeon Kim, Jong-Sun Lim, Jin-Young Cho, Heon Shin, Hyo Jin Lee, Byeong Jun Kang, Dai Hoon Han, Hoguen Kim, Ja-Hyun Baik, Magdalena Swiatek-de Lange, Johann Karl, Young-Ki Paik   +13 more
openaire   +4 more sources

In Vitro Drug Metabolism by Human Carboxylesterase 1: Focus on Angiotensin-Converting Enzyme Inhibitors [PDF]

Drug Metabolism and Disposition, 2014
Carboxylesterase 1 (CES1) is the major hydrolase in human liver. The enzyme is involved in the metabolism of several important therapeutic agents, drugs of abuse, and endogenous compounds. However, no studies have described the role of human CES1 in the activation of two commonly prescribed angiotensin-converting enzyme inhibitors: enalapril and ...
Thomsen, Ragnar, Rasmussen, Henrik B, Linnet, Kristian   +2 more
openaire   +4 more sources

Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis

PLoS ONE, 2022
Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation.
Bing Yang, Robert B. Parker, Bernd Meibohm, Zaid H. Temrikar, Ashish Srivastava, S. Casey Laizure   +5 more
doaj   +3 more sources

Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus. [PDF]

Pharmacogenet Genomics, 2016
CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Previous studies have reported a genomic translocation of the 5' region from the poorly expressed pseudogene CES1P1, to CES1, yielding the structural variant CES1VAR.
Sanford JC, Wang X, Shi J, Barrie ES, Wang D, Zhu HJ, Sadee W.   +6 more
europepmc   +4 more sources

Human Carboxylesterase 2 in Cocaine Metabolism [PDF]

, 2021
Increased hydrolysis of cocaine to non-toxic compounds is a promising way to prevent cocaine-induced toxicity. However, the short half-life of cocaine in the blood and the rapid conversion in the body to the hydrolysis-resistant metabolite ...
Alexandra T.P., Carvalho, Pedro R., Figueiredo, Ricardo D., González   +2 more
core   +1 more source