Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010 Two major isoforms of human carboxylesterases (CEs) are found in metabolically active tissues, CES1 and CES2. These hydrolytic enzymes are involved in xenobiotic and endobiotic metabolism. CES1 is abundantly expressed in human liver and monocytes/macrophages, including the THP1 cell line; CES2 is expressed in liver but not in monocytes/macrophages. The
J Allen, Crow +5 more
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Human carboxylesterase 1 active site structure. [PDF]
, 2013 Active site of human carboxylesterase 1 covalently inhibited via S221 with cyclosarin (magenta) [8]. The other catalytic residues, in addition to S221, are H468 and E354 (yellow), and are surrounded by hydrophobic residues (grey surface) including V146 ...
Steven L. Lewis (354519) +14 more
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A highly selective ratiometric fluorescent probe for invitro monitoring and cellular imaging of human carboxylesterase 1 [PDF]
, 2014 A highly selective ratiometric fluorescent probe for invitro monitoring and cellular imaging of human carboxylesterase
冯磊 +7 more
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Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]
PLoS ONE, 2011 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert +14 more
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Biodegradation of Fumonisins by the Consecutive Action of a Fusion Enzyme
Toxins, 2022 Fumonisins (FBs) are toxic mycotoxins that commonly exist in food and feed. FBs can induce many aspects of toxicity, leading to adverse effects on human and animal health; therefore, investigating methods to reduce fumonisin contamination is necessary ...
Kailin Li +5 more
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The novel nematicide wact-86 interacts with aldicarb to kill nematodes. [PDF]
PLoS Neglected Tropical Diseases, 2017 Parasitic nematodes negatively impact human and animal health worldwide. The market withdrawal of nematicidal agents due to unfavourable toxicities has limited the available treatment options.
Andrew R Burns +6 more
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Toxins, 2021 Fumonisin B1 (FB1) is the most common food-borne mycotoxin produced by the Fusarium species, posing a potential threat to human and animal health. Pigs are more sensitive to FB1 ingested from feed compared to other farmed livestock. Enzymatic degradation
Quancheng Liu +5 more
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Characterization of a mutant human erythrocyte carbonic anhydrase: Carbonic anhydrase IcGuam: The amino acid substitution and carboxylesterase and hydratase activities [PDF]
, 1966 Evidence is presented which indicates that an arginine residue has substituted for a glycine residue in the abnormal human erythrocyte carbonic anhydrase, CA IcGuam.
Yu, Ya-Shiou L. +2 more
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Frontiers in Cardiovascular Medicine, 2022 ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Haobo Li +35 more
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Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes [PDF]
, 2022 Vixotrigine is a voltage- and use-dependent sodium channel blocker under investigation for the potential treatment of neuropathic pain. One of the major in vivo metabolic pathways of vixotrigine in humans is the hydrolysis of the carboxamide to form the ...
Michael Rooney (1601641) +3 more
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