Results 61 to 70 of about 10,733 (194)

Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2 [PDF]

Archives of Biochemistry and Biophysics, 2006
Carboxylesterases hydrolyze a large array of endogenous and exogenous ester-containing compounds, including pyrethroid insecticides. Herein, we report the specific activities and kinetic parameters of human carboxylesterase (hCE)-1 and hCE-2 using authentic pyrethroids and pyrethroid-like, fluorescent surrogates.
Kosuke, Nishi, Huazhang, Huang, Shizuo G, Kamita, In-Hae, Kim, Christophe, Morisseau, Bruce D, Hammock   +5 more
openaire   +2 more sources

An In Vitro Evaluation of the Inhibition of Recombinant Human Carboxylesterase-1 by Herbal Extracts

Journal of Natural Health Product Research, 2021
Abstract INTRODUCTION: Methylphenidate is a psychostimulant prescribed for symptoms of attention-deficit hyperactivity disorder (ADHD), and is metabolized by carboxylesterase-1 (CES1) enzyme. There is little information on herbal medicine used for ADHD and their interactions with CES1.
Hajra Mazhar, Philippe Robaey, Cory Harris   +2 more
openaire   +2 more sources

Identification of resistant carboxylesterase alleles in Culex pipiens complex via PCR-RFLP [PDF]

, 2012
Background Carboxylesterase overproduction is a frequently observed resistance mechanism of insects to organophosphate insecticides. As a major transmitter of human diseases, mosquitoes in the Culex pipiens complex have evolved 13 carboxylesterase ...
Zhang Hanying, Cui Feng, Meng Fengxia, Qiao Chuanling   +3 more
core   +1 more source

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans. [PDF]

PLoS ONE, 2017
Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, a prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease
Jaeseong Oh, SeungHwan Lee, Howard Lee, Joo-Youn Cho, Seo Hyun Yoon, In-Jin Jang, Kyung-Sang Yu, Kyoung Soo Lim   +7 more
doaj   +1 more source

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin [PDF]

, 2009
Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholin-ergic crisis. Development of protein-based therapeutics is be-ing pursued with the goal of preventing nerve agent toxicity and ...
Monika Wierdl, Mary Macdonald, Tamara C. Otto, Matthew R. Redinbo, Fleming, C. D., Hemmert, A. C., Douglas M. Cerasoli, MacDonald, M., Cashman, J. R., Christopher D. Fleming, Edwards, C. C., Carol C. Edwards, Andrew C. Hemmert, Wierdl, M., Potter, P. M., Philip M. Potter, Redinbo, M. R., John R. Cashman, Otto, T. C., Cerasoli, D. M.   +19 more
core   +2 more sources

Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs

Molecular Therapy: Nucleic Acids, 2013
MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (shiCE).
Kazue Kasai, Hiroshi Nakashima, Fang Liu, Samantha Kerr, Jiang Wang, Mitch Phelps, Philip M Potter, William B Goins, Soledad A Fernandez, E Antonio Chiocca   +9 more
doaj   +1 more source

Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008
Cholesteryl esters are hydrolyzed by cholesteryl ester hydrolase (CEH) yielding free cholesterol for export from macrophages. Hence, CEH has an important regulatory role in macrophage reverse cholesterol transport (RCT). CEH and human carboxylesterase 1 (CES1) appear to be the same enzyme.
J Allen, Crow, Brandy L, Middleton, Abdolsamad, Borazjani, M Jason, Hatfield, Philip M, Potter, Matthew K, Ross   +5 more
openaire   +2 more sources

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie International Edition, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +1 more source

Carboxylesterase 1 and Precision Pharmacotherapy [PDF]

, 2021
Carboxylesterase 1 (CES1) is a major phase I drug-metabolizing enzyme, responsible for 80-95% of total hydrolytic activity in human livers. CES1 plays a crucial role in the metabolism of a wide range of drugs, pesticides, environmental pollutants, and ...
Her, Lucy
core   +1 more source

Rapid bioluminescence assay for monitoring rat CES1 activity and its alteration by traditional Chinese medicines

Journal of Pharmaceutical Analysis, 2020
In traditional Chinese medicine herbs (TCM), including Radix Salviae Miltiorrhizae (Danshen), Radix Puerariae Lobatae (Gegen), Radix Angelicae Sinensis (Danggui), and Rhizoma Chuanxiong (Chuanxiong) are widely used for the prevention and treatment of ...
Jun Zhang, Dandan Wang, Liwei Zou, Min Xiao, Yufeng Zhang, Ziwei Li, Ling Yang, Guangbo Ge, Zhong Zuo   +8 more
doaj   +1 more source