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Human cytomegalovirus: taking the strain [PDF]

Medical Microbiology and Immunology, 2015
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently needed treatments.
Aicheler, Rebecca, Davison, Andrew J., Fielding, Ceri A., Lehner, Paul J., Murrell, Isa, Seirafian, Sepher, Stanton, Richard J., Tomasec, Peter, Wang, Edward C. Y., Weekes, Michael, Wilkie, Gavin, Wilkinson, Gavin W. G.   +11 more
core   +8 more sources

High-Risk Oncogenic Human Cytomegalovirus

Viruses, 2022
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the population worldwide, usually without symptoms. The host immune response keeps the virus in a latent stage, although HCMV can reactivate in an inflammatory context ...
Georges Herbein
doaj   +2 more sources

MicroRNAs expressed by human cytomegalovirus

Virology Journal, 2020
Background MicroRNAs (miRNAs) are small non-coding RNAs about 22 nucleotides in length, which play an important role in gene regulation of both eukaryotes and viruses.
Lichen Zhang, Jiaqi Yu, Zhijun Liu
doaj   +2 more sources

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

Haematologica, 2016
We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological malignancies, who had received a HLA-haploidentical hematopoietic stem cell transplantation, depleted ...
Letizia Muccio, Alice Bertaina, Michela Falco, Daniela Pende, Raffaella Meazza, Miguel Lopez-Botet, Lorenzo Moretta, Franco Locatelli, Alessandro Moretta, Mariella Della Chiesa   +9 more
doaj   +2 more sources

Vaccination against the human cytomegalovirus

Vaccine, 2019
The human cytomegalovirus (HCMV) is the most important infectious cause of congenital abnormalities and also of infectious complications of transplantation. The biology of the infection is complex and acquired immunity does not always prevent reinfection.
S. Plotkin, Suresh B. Boppana
semanticscholar   +3 more sources

Murine Cytomegalovirus and Human Cytomegalovirus Differ in Pyroptosis Induction in Different Cell Types During Productive Replication [PDF]

Viruses
Pyroptosis is a proinflammatory programmed cell death (PCD) that protects the host against invading viruses. We previously reported that pyroptosis plays a prominent role in the pathogenesis of murine cytomegalovirus (MCMV) retinal necrosis using mice ...
Jessica J. Carter, Daniel H. Schneider, Arshaan M. Hisamuddin, Richard D. Dix   +3 more
doaj   +2 more sources

Effect of host telomerase inhibition on human cytomegalovirus [PDF]

Journal of Virology
Treatment options remain limited for human cytomegalovirus (HCMV). Host telomerase has been implicated in the pathogenesis and oncogenesis of multiple herpesviruses, most recently including HCMV.
Chloe M. Cavanaugh, Cora N. Betsinger, Nicole Katchur, Sherry Zhang, Karen Yang, Maciej Nogalski, Ileana M. Cristea, Daniel Notterman   +7 more
doaj   +2 more sources

Human cytomegalovirus: pathogenesis, prevention, and treatment [PDF]

Molecular Biomedicine
Human cytomegalovirus (HCMV) infection remains a significant global health challenge, particularly for immunocompromised individuals and newborns. This comprehensive review synthesizes current knowledge on HCMV pathogenesis, prevention, and treatment ...
Zifang Shang, Xin Li
doaj   +2 more sources

Pathogenesis of human cytomegalovirus in the immunocompromised host

Nature Reviews Microbiology, 2021
Human cytomegalovirus (HCMV) is a herpesvirus that infects ~60% of adults in developed countries and more than 90% in developing countries. Usually, it is controlled by a vigorous immune response so that infections are asymptomatic or symptoms are mild ...
P. Griffiths, M. Reeves
semanticscholar   +1 more source

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

Science Advances, 2021
Prefusion human cytomegalovirus glycoprotein B structure reveals the structural basis for membrane fusion. Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity.
Yuhang Liu, Kyle P. Heim, Y. Che, X. Chi, X. Qiu, Seungil Han, P. Dormitzer, Xinzhen Yang   +7 more
semanticscholar   +1 more source