Peripheral-neuron-like properties of differentiated human dental pulp stem cells (hDPSCs). [PDF]
PLoS ONE, 2021 Elucidating the mechanisms underlying human pain sensation requires the establishment of an in vitro model of pain reception comprising human cells expressing pain-sensing receptors and function properly as neurons.
Yuki Arimura +8 more
doaj +2 more sources
Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2-Modulated Exosome Release. [PDF]
Adv Sci (Weinh)Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Jin B +10 more
europepmc +2 more sources
Secreted Peptidome Profiling of Human Dental Pulp Stem Cells–Conditioned Medium During Odontogenic Differentiation [PDF]
International Dental JournalIntroduction and Aims: Odontogenic differentiation of human dental pulp stem cells (hDPSCs) is critical for pulp repair. This study aims to characterise the secretory peptidome of human dental pulp stem cells (hDPSCs) during odontogenic differentiation ...
Yanhua Huang +6 more
doaj +2 more sources
Therapeutic potential of melatonin-pretreated human dental pulp stem cells (hDPSCs) in an animal model of spinal cord injury [PDF]
Scientific ReportsDental pulp stem cells (DPSCs) show potential for treating neurodegenerative and traumatic diseases due to their neural crest origin. Melatonin (MT), an endogenous neurohormone with well-documented anti-inflammatory and antioxidant properties, has shown ...
Arvin Naeimi +4 more
doaj +2 more sources
Mechanosensitive PIEZO1 Regulates Angiogenic Signaling in Human Dental Pulp Stem Cells. [PDF]
Cell Biochem FunctABSTRACT Dental pulp stem cells (DPSCs) possess multilineage differentiation potential and contribute to dental pulp regeneration through odontoblast replacement and neovascularization. Although mechanosensitive ion channels such as PIEZO1 are known to regulate stem cell fate, their role in DPSC‐mediated angiogenesis under mechanical stress remains ...
Orimoto A +3 more
europepmc +2 more sources
Inhibition of miR-224-5p promotes osteogenesis in dental pulp stem cells by targeting the PTEN/PI3K/AKT axis [PDF]
Journal of Orthopaedic Surgery and ResearchBackground MiR-224-5p has been proven to play an important role in regulating cell differentiation. This study aimed to clarify the regulatory role and mechanism of miR-224-5p in the osteogenic differentiation of human dental pulp stem cells (hDPSCs ...
Zhihong Ke +3 more
doaj +2 more sources
The effect of different pulp-capping materials on proliferation, migration and cytokine secretion of human dental pulp stem cells [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Biocompatibility of dental biomaterials plays a critical role in regeneration of dental stem cells. The aim of present study was to evaluate the effects of novel biomaterials of TheraCal-LC (TheraCal; Bisco), Angelus mineral trioxide ...
Salma Omidi +3 more
doaj +1 more source
Bioprinted PDLSCs with high-concentrated GelMA hydrogels enhances osteogenic differentiation
International Dental Journal, 2023 Aim or Purpose: Regeneration of sensory nerves is challenging in dental pulp regeneration. Schwann cells (SCs) are essential glial cells conducive to regenerating dental pulp sensory nerve, but their source is scarce.
Dr Changyong Yuan +2 more
doaj +1 more source
Biomedicines, 2022 Dental pulp is a major component of the dental body that serves to maintain the tooth life and function. The aim of the present work was to develop a system that functions as a growth-permissive microenvironment for dental pulp regeneration using a ...
Francesca Diomede +7 more
doaj +1 more source
Scientific Reports, 2021 Calcium (Ca2+) signalling plays an indispensable role in dental pulp and dentin regeneration, but the Ca2+ responses of human dental pulp stem cells (hDPSCs) stimulated with tricalcium silicate-based (TCS-based) dental biomaterials remains largely ...
Elanagai Rathinam +7 more
doaj +1 more source