Results 61 to 70 of about 466,085 (286)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Embryonic Stem Cell Research

Voices in Bioethics, 2019
Introduction In November 1998, two teams of U.S. scientists confirmed successful isolation and growth of stems cells obtained from human fetuses and embryos.
Lillian Nwigwe
doaj   +1 more source

Derivation of rhesus monkey parthenogenetic embryonic stem cells and its microRNA signature. [PDF]

PLoS ONE, 2011
Parthenogenetic embryonic stem cells are considered as a promising resource for regeneration medicine and powerful tools for developmental biology. A lot of studies have revealed that embryonic stem cells have distinct microRNA expression pattern and ...
Qiang Wei, Zhenghua Sun, Xiechao He, Tao Tan, Bin Lu, Xiangyu Guo, Bing Su, Weizhi Ji   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Embryonic Stem Cell Research as an Ethical Issue: On the Emptiness of Symbolic Value [PDF]

, 2001
The debate over human embryonic stem cell research-scientific and clinical prospects as well as ethical implications-became front-page news only after two teams of university researchers reported in November 1998 that they had isolated and cultured human
Quinn, Kevin P.
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells [PDF]

, 2009
July 3, 2012Both human embryonic stem cells and induced pluripotent stem cells can self-renew indefinitely in culture; however, present methods to clonally grow them are inefficient and poorly defined for genetic manipulation and therapeutic purposes ...
A Delcorte, AJ Engler, AJ Urquhart, AJ Urquhart, AM Lipski, Andrew L. Hook, BG Keselowsky, C Xu, D Hockemeyer, D Hockemeyer, Daniel G. Anderson, DG Anderson, E Luther, EG Hayman, F Guilak, Fredrick Rojas, G Constantinides, GQ Daley, J Yu, J Zou, JA Thomson, JC Vickerman, Jing Yang, JJ Green, K Saha, K Saha, K Takahashi, K Watanabe, Krishanu Saha, Krystyn J. Van Vliet, LG Villa-Diaz, M Amit, M Amit, Maisam Mitalipova, Martyn C. Davies, Morgan R. Alexander, MT Thompson, Neena Pyzocha, P Stojkovic, PA Underwood, PB van Wachem, R Peerani, Robert Langer, Rudolf Jaenisch, S Gerecht, S Neuss, S Rodin, S Yao, Said R. Bogatyrev, Seung-Woo Cho, SR Braam, TE Ludwig, TE Ludwig, TP Zwaka, WC Oliver, Y Li, Y Mei, Y Meng, Y Tamada, Y Tamada, Y-T Cheng, Ying Mei, YJ Li, Z Melkoumian, Z. Ilke Kalcioglu   +64 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Nucleosome Organization in Human Embryonic Stem Cells. [PDF]

PLoS ONE, 2015
The fundamental repeating unit of eukaryotic chromatin is the nucleosome. Besides being involved in packaging DNA, nucleosome organization plays an important role in transcriptional regulation and cellular identity.
Puya G Yazdi, Brian A Pedersen, Jared F Taylor, Omar S Khattab, Yu-Han Chen, Yumay Chen, Steven E Jacobsen, Ping H Wang   +7 more
doaj   +1 more source

Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. [PDF]

, 2013
While adult heart muscle is the least regenerative of tissues, embryonic cardiomyocytes are proliferative, with embryonic stem (ES) cells providing an endless reservoir.
Arshi, Armin, Eaimkhong, Sarayoot, Evseenko, Denis, Gimzewski, James K, Nakano, Atsushi, Nakano, Haruko, Nakashima, Yasuhiro, Reed, Jason, Stieg, Adam Z   +8 more
core   +2 more sources