Results 111 to 120 of about 17,528,888 (291)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Eyes and movement differences in unconscious state during microscopic procedures
Scientific ReportsMicrosurgery is one of the techniques that is increasingly being adopted in many surgical fields. However, the acquisition and transfer of microsurgical skills primarily depend on experience.
Akiko Fujita +6 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde AnglophoneThis paper investigates the portrayal of life as a universal principle in contemporary North American speculative fiction, examining narratives that leverage the “greater good” of human survival to promote the idea of human enhancement.
Loredana Filip
doaj +1 more source
Enhancing the collectivist critique: accounts of the human enhancement debate. [PDF]
Med Health Care Philos, 2021 Johnson T.
europepmc +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Anthropological Arguments in the Ethical Debate about Human Enhancement
Humana.Mente: Journal of Philosophical Studies, 2014 The paper discusses the role of anthropological arguments in contemporary ethics as exemplified in the current debate about biotechnological human enhancement interventions. Anthropological arguments refer to a normative conception of what it means to be
Jan-Christoph Heilinger
doaj
Why catastrophic events, human enhancement and progress in robotics may limit individual health rights. [PDF]
Monash Bioeth Rev, 2022 Szocik K.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Humana.Mente: Journal of Philosophical Studies, 2014 The essay is subdivided into three parts. In the first and introductory one the current debate on human enhancement is presented, with specific reference to its interdisciplinary characteristics and to the aspects which explicitly challenge “the human ...
Alberto Pirni
doaj