Results 81 to 90 of about 17,528,888 (291)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Ethical and legal considerations of mood enhancement technology
Frontiers in Human DynamicsTechnology qualifying as human mood enhancement can be developed, on the one hand, for the well-being and mental health of their users (therapy) and, on the other hand, for changing the mood of their users above levels of normality (enhancement).
Erik Kamenjasevic
doaj +1 more source
Approaching Subjectivity. On “The Dispute About Subjectivity: Interdisciplinary Perspective”
Ethics in Progress, 2018 The review paper revisits the problem of subjectivity with particular focus on the latest research in this field presented in The Dispute about Subjectivity – an Interdisciplinary Perspective, edited by Adriana Warmbier (2016). I pay special attention to
Karolina Napiwodzka
doaj +1 more source
, 2014 Two major problems persist in the debate regarding the ethics of human enhancement. First, there is a lack of discussion and agreement on a definition of human enhancement. Second, the commonly used bioethical principles of justice, safety, and autonomy are jointly insufficient to assess the morality of human enhancement.
Roduit Johann A R +2 more
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
THE THEOLOGICAL DEBATE OVER HUMAN ENHANCEMENT: AN EMPIRICAL CASE STUDY OF A MEDIATING ORGANIZATION
Zygon, 2020 For most theologians, theology should ultimately be used by the laity and/or the public. However, the religion and science debate has not focused on the divide between theologians and the laity.
doaj +2 more sources
Frontiers in Genetics, 2017 While gene doping and other technological means of sport enhancement have become a topic of ethical debate, a major outcome from genomic research in sports is often linked to the regulation of doping.
Jaehwan Hyun
doaj +1 more source