Results 11 to 20 of about 201,143 (234)

Regulation (EU) No 536/2014 on clinical trials on medicinal products for human use: an overview

open access: yesAnnali dell'Istituto Superiore di Sanità, 2014
For the 28 member states of the European Union, Regulation (EU) No 536/2014 on clinical trials on medicinal products for human use, which repeals Directive 2001/20/EC, represents a substantial innovation in the procedures for authorising clinical trials ...
Carlo Petrini
doaj   +1 more source

“Localising Tropical Medicine”: A History of the Medical Research Institute (MRI) in Colonial Lagos, 1907–1920s

open access: yesModern Africa, 2021
This article explores an early episode in the history of tropical medicine in colonial Lagos, British West Africa. It probes into the activities and outputs of scientists who operated within the Medical Research Institute (MRI) as a way to further ...
Adedamola Seun Adetiba
doaj   +1 more source

Festina lente

open access: yesContemporary Clinical Trials Communications, 2021
The provisions adopted in Italy for clinical trials on medicinal products and medical devices for the epidemiological emergency caused by COVID-19 had an impact also on the functioning of Ethics Committees (ECs).
Carlo Petrini, Walter Ricciardi
doaj   +1 more source

Of Mice and Men: Violence and Human Experimentation

open access: yesState Crime, 2013
Unethical human experimentation has long been a murky feature of medical research, most notoriously in the death camps of Nazi Germany. Despite the subsequent creation of the Nuremberg Code principles for the protection of human subjects, harmful medical
Paddy Rawlinson
doaj   +1 more source

The effectiveness of human resources practices in driving proactive experimentation and risk-taking work behaviours in organisations

open access: yesSA Journal of Human Resource Management, 2020
Orientation: Proactive experimentation and risk-taking employee behaviours have received considerable attention both empirically and conceptually in organisational learning and development studies, as well as in relation to organisational innovation ...
Rose B. Mathafena, Anton Grobler
doaj   +1 more source

Increased PIO2 at exhaustion in hypoxia enhances muscle activation and swiftly relieves fatigue: a placebo or a PIO2 dependent effect?

open access: yesFrontiers in Physiology, 2016
To determine the level of hypoxia from which muscle activation (MA) is reduced during incremental exercise to exhaustion (IE), and the role played by PIO2 in this process, ten volunteers (21±2 years) performed four IE in severe acute hypoxia (SAH) (PIO2 ...
Rafael Torres-Peralta   +12 more
doaj   +1 more source

Ética e pesquisa

open access: yesActa Cirúrgica Brasileira, 2008
OBJETIVO: O presente artigo tem por objetivo explanar os aspectos éticos das experimentações em seres humanos e animais. CONTEÚDO: O tema abordado é de suma importância, pois almeja-se que o ser humano atinja seu bem-estar físico, mental, social e ...
Taylor Brandão Schnaider
doaj   +1 more source

Experimentation as a didactic strategy in science teaching with elementary school students

open access: yesDiversitas Journal, 2023
Science Teaching has been discussed in the educational field regarding its methodological strategies on how to improve experimental activities that arouse students' curiosity and, consequently, stimulate practical teaching that is different from ...
Rosineide Nascimento da Silva   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

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