Results 121 to 130 of about 9,687,585 (343)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Human and organizational factors within the public sectors for the prevention and control of epidemic

, 2020
Lipeng Fu, Xueqing Wang, Dan Wang, Mark Griffin, Peixuan Li   +4 more
openalex   +2 more sources

Loss of Interleukin-10 or Transforming Growth Factor β Signaling in the Human Colon Initiates a T-Helper 1 Response Via Distinct Pathways [PDF]

, 2011
Anne Jarry, Céline Bossard, Guillaume Sarrabayrouse, Jean‐François Mosnier, Christian Laboisse   +4 more
openalex   +1 more source

Global incidence and mortality trends of corpus uteri cancer and associations with gross domestic product, human development index, lifestyle, and metabolic risk factors [PDF]

, 2023
Junjie Huang, Wing Chung Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero‐Prisno, Wanghong Xu, Zhi‐Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong   +10 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Synchronization-based fusion of EEG and eye blink signals for enhanced decoding accuracy

Scientific Reports
Decoding locomotor tasks is crucial in cognitive neuroscience for understanding brain responses to physical tasks. Traditional methods like EEG offer brain activity insights but may require additional modalities for enhanced interpretative precision and ...
Emad Alyan, Stefan Arnau, Julian Elias Reiser, Edmund Wascher   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Changes of cognitive functions and proinflammatory cytokines across the lifespan in latent Toxoplasma gondii infection

Brain, Behavior, & Immunity - Health
Background: Recent findings showed serious consequences of latent T. gondii infection on the central nervous system, leading to psychiatric, immunological and cognitive impairments.
Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Jörg Reinders, Carsten Watzl, Edmund Wascher, Stephan Getzmann   +8 more
doaj   +1 more source

Myricitrin inhibits vascular endothelial growth factor-induced angiogenesis of human umbilical vein endothelial cells and mice

, 2020
Zhipeng Hu, Gang Zhao, Wei Gou, Hua Cheng   +3 more
openalex   +1 more source

Human epidermal growth factor receptor 2 status of gastric cancer patients in Asia: results from a large, multicountry study [PDF]

, 2016
Nirmala Pathmanathan, Jingshu Geng, Wencai Li, Xiu Nie, Januario Veloso, John Wang, Julie Hill, Philip McCloud, Michael Bilous   +8 more
openalex   +1 more source