FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Immunohistochemical Localization of Insulin-like Growth Factor (IGF-I), IGF-I Receptor, and IGF Binding Proteins 1–4 in Human Fallopian Tube at Various Reproductive Stages [PDF]
, 1994 Thea L. Pfeifer, Nasser Chegini
openalex +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
A Convolutional Neural Network as a Potential Tool for Camouflage Assessment
Applied SciencesCamouflage evaluation is traditionally evaluated through human visual search and detection experiments, which are time-consuming and resource intensive.
Erik Van der Burg +3 more
doaj +1 more source
Functional Studies of Human Decidua in Spontaneous Early Pregnancy Loss: Effect Of Soluble Factors and Purified CD56+ Lymphocytes on Killing of Natural Killer and Lymphokine-Activated Killer-Sensitive Targets1 [PDF]
, 1998 N. Vassiliadou, Judith N. Bulmer
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Glycosaminoglycans in human retinoblastoma cells: Heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions [PDF]
, 2003 Elena Alberdi +2 more
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The significance of Fibroblast growth factor 23 (FGF-23) in humans
, 2021 Altynay Balmukhanova +4 more
openalex +2 more sources