Results 121 to 130 of about 10,781,581 (397)

Methodologies for Transcript Profiling Using Long-Read Technologies

Frontiers in Genetics, 2020
RNA sequencing using next-generation sequencing technologies (NGS) is currently the standard approach for gene expression profiling, particularly for large-scale high-throughput studies.
Spyros Oikonomopoulos, Anthony Bayega, Somayyeh Fahiminiya, Haig Djambazian, Pierre Berube, Jiannis Ragoussis, Jiannis Ragoussis   +6 more
doaj   +1 more source

A Compressed Self-Index for Genomic Databases [PDF]

arXiv, 2011
Advances in DNA sequencing technology will soon result in databases of thousands of genomes. Within a species, individuals' genomes are almost exact copies of each other; e.g., any two human genomes are 99.9% the same. Relative Lempel-Ziv (RLZ) compression takes advantage of this property: it stores the first genome uncompressed or as an FM-index, then
arxiv  

Chromosomal rearrangements as barriers to genetic homogenization between archaic and modern humans [PDF]

, 2015
Chromosomal rearrangements, which shuffle DNA throughout the genome, are an important source of divergence across taxa. Using a paired-end read approach with Illumina sequence data for archaic humans, I identify changes in genome structure that occurred recently in human evolution. Hundreds of rearrangements indicate genomic trafficking between the sex
arxiv   +1 more source

Origins of the Human Genome Project [PDF]

, 1994
Dr. Cook-Deegan recounts some of the scientific and political history leading to controversy about the proper mix of private and public roles in pursuing genome research and bringing its fruits to bear, e.g., in preventing and curing ...
Cook-Deegan, Robert Mullan
core   +1 more source

The accessible chromatin landscape of the human genome

Nature, 2012
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions.
R. Thurman, Eric Rynes, R. Humbert, J. Vierstra, Matthew T. Maurano, E. Haugen, Nathan C. Sheffield, A. Stergachis, Hao Wang, Benjamin Vernot, Kavita S Garg, R. Sandstrom, Daniel Bates, T. Canfield, Morgan Diegel, D. Dunn, Abigail K. Ebersol, Tristan Frum, Erika Giste, Lisa Harding, Audra K. Johnson, Ericka M. Johnson, T. Kutyavin, B. Lajoie, Bum-Kyu Lee, Kristen Lee, D. London, D. Lotakis, Shane J. Neph, Fidencio J. Neri, Eric D Nguyen, Alex P. Reynolds, V. Roach, Alexias Safi, Minerva E. Sanchez, Amartya Sanyal, A. Shafer, Jeremy M. Simon, Lingyun Song, Shinny Vong, M. Weaver, Zhancheng Zhang, Zhuzhu Zhang, B. Lenhard, M. Tewari, M. Dorschner, R. Hansen, P. Navas, G. Stamatoyannopoulos, V. Iyer, J. Lieb, S. Sunyaev, J. Akey, P. Sabo, R. Kaul, T. Furey, J. Dekker, G. Crawford, J. Stamatoyannopoulos   +58 more
semanticscholar   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

Novel variant in WT1 gene associated with MGD and unique kidney disease phenotype

Journal of Rare Diseases
Introduction Wilms tumor 1 (WT1)-related disorders are a group of hereditary disorders caused by alterations in the WT1 gene. WT1 expression is critical for the maturation of many organs, such as the gonads, kidneys, and spleen.
Heba A. Hassan, Inas Mazen, Mona K. Mekkawy, Aya Elaidy, Alaa Kamel, Mona L. Essawi   +5 more
doaj   +1 more source

copMEM: Finding maximal exact matches via sampling both genomes [PDF]

arXiv, 2018
Genome-to-genome comparisons require designating anchor points, which are given by Maximum Exact Matches (MEMs) between their sequences. For large genomes this is a challenging problem and the performance of existing solutions, even in parallel regimes, is not quite satisfactory.
arxiv  

The Human Genome [PDF]

Heredity, 2003
The Human Genome is a beautifully assembled and well-written publication, enriched with high-quality photographs and diagrams that will appeal to both students and professional scientists and educators. This seven-chapter book begins with an appropriate foreword by Nobel laureate James Watson, the codiscoverer of the structure of DNA.
openaire   +1 more source

The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode [PDF]

, 2005
Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even
, Akman, Alla Lapidus, Altschul, Altschul, Amiri, Anamitra Bhattacharyya, Andersson, Andersson, Aras, Aultman, Balakirev, Bandi, Bandi, Bandi, Bandi, Bandi, Barker, Barton Slatko, Bazzocchi, Bazzocchi, Beard, Besemer, Booth, Bordenstein, Bordenstein, Bosshardt, Bourtzis, Bourtzis, Brattig, Brattig, Brattig, Brayton, Brenot, Campbell, Casiraghi, Casiraghi, Casiraghi, Caturegli, Chirgwin, Chirgwin, Chirgwin, Cloud, Collins, Cross, Curtis, Daubin, den Blaauwen, Dobson, Donald Comb, Dumler, Durvasula, Egyed, Elodie Ghedin, Eugene Goltsman, Eugene Koonin, Ewing, Ewing, Fischer, Flieger, Foster, Francis, Freedman, Genchi, Genchi, Ghedin, Gil, Gordon, Gouin, Grant, Grigoriev, Haarbrink, Haarbrink, Hall, Hise, Hise, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoffman, Hougard, Howell, Ibrahim Kamal, Janos Posfai, Jeng, Jennifer Ware, Jeremy Foster, Jessica Ingram, Jeyaprakash, Jolodar, Kanehisa, Keiser, King, Kira Makarova, Kiryl Tsukerman, Klasson, Kozek, Kozek, Kramer, Kuhn, Kumar, Kurtz, Lamb, Langworthy, Larson, Laurie Moran, Laven, Letunic, Li, Lin, Lin, Lo, Locht, Lowe, MacDonald, Mackenzie, Makarova, Marina Omelchenko, McGuffin, McLaren, Mehul Ganatra, Mikhail Mazur, Mira, Molyneux, Moran, Moran, Moran, Moran, Nancy A. Moran, Narita, Natalia Ivanova, Nielsen, Nikos Kyrpides, O'Neill, Olga Ostrovskaya, Ottesen, Ottesen, Ottesen, Overbeek, Pearlman, Plenge-Bonig, Powell, Powell, Prichard, Prichard, Punkosdy, Rajan, Rao, Rao, Rao, Reader, Richards, Roux, Rubtsov, Saint Andre, Sanjay Kumar, Selkirk, Sexton, Shigenobu, Shiliang Wang, Shukla-Dave, Sinkins, Sinkins, Sinkins, Sironi, Slatko, Slesarev, Smith, Suetsugu, Sun, Tamas, Tamas, Tamas Vincze, Tatusov, Taylor, Taylor, Taylor, Taylor, Taylor, Taylor, Taylor, Townson, van Ham, Vandekerckhove, Victor Joukov, Vinayak Kapatral, Vincent, Warbrick, Ware, Warren, Wernegreen, Wernegreen, Werren, Werren, Werren, Werren, Williams, Wolf, Wu, Zabalou   +204 more
core   +3 more sources