Results 211 to 220 of about 2,026,261 (344)

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Interplay of the Genetic Variants and Allele Specific Methylation in the Context of a Single Human Genome Study. [PDF]

Int J Mol Sci
Voronina MD, Zayakina OV, Deinichenko KA, Shingalieva OS, Tsimmer OY, Tarasova DA, Grebnev PA, Snigir EA, Mitrofanov SI, Yudin VS, Keskinov AA, Yudin SM, Svetlichnyy DV, Skvortsova VI.   +13 more
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

DNA Methylation at a Single Locus of Human Genome Accurately Recapitulates Episignature of CREBBP-Related Rubinstein-Taybi Syndrome. [PDF]

Int J Mol Sci
Zemlianaia OA, Kalinkin AI, Tanas AS, Efremova AV, Volodin IV, Ismagilova OR, Smirnov AS, Zaletaev DV, Nemtsova MV, Kutsev SI, Strelnikov VV.   +10 more
europepmc   +1 more source

Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage [PDF]

, 1990
Claude Hamelin, Michel Dion
openalex   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

P170: Leveraging a genotype-first approach in All of Us cohort to describe prevalence and phenotypic spectrum of rare genetic disorders*

Genetics in Medicine Open
Katharine Chaillet, Jonas Ladenson, Anna Noreuil, Katherine Leopold, Robert Hubley, Shannon Haines, Joshua Denny, Huan Mo, Oleg Shchelochkov   +8 more
doaj   +1 more source

The impact of the three major human genome editing reports on the governance landscape. [PDF]

J Community Genet
Conley J, Robinson A, Wilson R, Kuczynski K, Henderson G.   +4 more
europepmc   +1 more source

Molecular epidemiology of human rotaviruses in Melbourne, Australia, from 1973 to 1979, as determined by electrophoresis of genome ribonucleic acid

, 1981
Suzanne M. Rodger, Ruth F. Bishop, Christopher Birch, B McLean, Ian Holmes   +4 more
openalex   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source