Results 121 to 130 of about 948,823 (313)
Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda +12 morewiley +1 more sourceLandscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno +5 morewiley +1 more sourceIdentification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
Nature, 2007 E. Birney, J. Stamatoyannopoulos, A. Dutta, R. Guigó, T. Gingeras, E. Margulies, Z. Weng, M. Snyder, E. Dermitzakis, R. Thurman, Michael S. Kuehn, Christopher M. Taylor, Shane J. Neph, Christoph M. Koch, S. Asthana, A. Malhotra, I. Adzhubei, J. Greenbaum, R. Andrews, Paul Flicek, Patrick J Boyle, Hua Cao, N. Carter, Gayle K. Clelland, S. Davis, Nathan Day, P. Dhami, Shane C. Dillon, M. Dorschner, H. Fiegler, P. Giresi, Jeff Goldy, M. Hawrylycz, Andrew K. Haydock, R. Humbert, K. James, Brett E. Johnson, Ericka M. Johnson, Tristan Frum, Elizabeth R. Rosenzweig, N. Karnani, K. Lee, Gregory Lefebvre, P. Navas, Fidencio V. Neri, Stephen C. J. Parker, P. Sabo, R. Sandstrom, A. Shafer, D. Vetrie, M. Weaver, S. Wilcox, Man Yu, F. Collins, J. Dekker, J. Lieb, T. Tullius, G. Crawford, S. Sunyaev, W. S. Noble, I. Dunham, F. Denoeud, A. Reymond, P. Kapranov, J. Rozowsky, D. Zheng, R. Castelo, A. Frankish, J. Harrow, Srinka Ghosh, A. Sandelin, I. Hofacker, R. Baertsch, Damian Keefe, S. Dike, Jill Cheng, H. Hirsch, E. Sekinger, Julien Lagarde, J. F. Abril, Atif Shahab, Christoph Flamm, C. Fried, J. Hackermüller, Jana Hertel, Manja Lindemeyer, Kristin Missal, Andrea Tanzer, Stefan Washietl, J. Korbel, O. Emanuelsson, J. S. Pedersen, N. Holroyd, Ruth Taylor, D. Swarbreck, N. Matthews, M. Dickson, D. Thomas, M. Weirauch, J. Gilbert, J. Drenkow, I. Bell, X. Zhao, K. Srinivasan, W. Sung, H. Ooi, K. Chiu, S. Foissac, T. Alioto, M. Brent, L. Pachter, M. Tress, A. Valencia, S. Choo, C. Choo, C. Ucla, C. Manzano, Carine Wyss, E. Cheung, T. Clark, James B. Brown, M. Ganesh, Sandeep Patel, H. Tammana, Jacqueline Chrast, Charlotte N. Henrichsen, C. Kai, J. Kawai, Ugrappa Nagalakshmi, Jiaqian Wu, Zheng Lian, Jin Lian, P. Newburger, Xueqing Zhang, P. Bickel, J. Mattick, Piero Carninci, Y. Hayashizaki, S. Weissman, T. Hubbard, R. M. Myers, J. Rogers, P. Stadler, T. Lowe, Chia-Lin Wei, Y. Ruan, K. Struhl, M. Gerstein, S. Antonarakis, Yutao Fu, E. Green, Ulas Karaöz, A. Siepel, James Taylor, L. Liefer, K. Wetterstrand, P. Good, E. Feingold, M. Guyer, G. Cooper, G. Asimenos, Colin N. Dewey, Minmei Hou, S. Nikolaev, J. Montoya-Burgos, A. Löytynoja, S. Whelan, F. Pardi, Tim Massingham, Haiyan Huang, Na Zhang, I. Holmes, J. Mullikin, A. Ureta-Vidal, B. Paten, Michael R. Seringhaus, D. Church, K. Rosenbloom, W. Kent, Eric A. Stone, S. Batzoglou, N. Goldman, R. Hardison, D. Haussler, Webb Miller, A. Sidow, N. Trinklein, Zhengdong D. Zhang, Leah Barrera, R. Stuart, D. King, A. Ameur, Stefan Enroth, M. Bieda, Jonghwan Kim, A. Bhinge, N. Jiang, Jun Liu, Fei Yao, V. Vega, C. Lee, Patrick Ng, A. Yang, Z. Moqtaderi, Zhou Zhu, Xiaoqin Xu, S. Squazzo, M. Oberley, David Inman, Michael A. Singer, T. Richmond, Kyle J. Munn, Á. Rada-Iglesias, O. Wallerman, J. Komorowski, J. Fowler, Phillippe Couttet, Alexander W. Bruce, O. Dovey, P. Ellis, C. Langford, D. Nix, G. Euskirchen, S. Hartman, A. Urban, P. Kraus, Sara Van Calcar, Nathaniel D. Heintzman, Tae Hoon Kim, Kun Wang, Chunxu Qu, G. Hon, R. Luna, C. Glass, M. Rosenfeld, S. F. Aldred, S. Cooper, Anason S. Halees, J. M. Lin, H. Shulha, Xiaoling Zhang, Mousheng Xu, Jaafar N. Haidar, Yon-Jong Yu, V. Iyer, Roland Green, C. Wadelius, P. Farnham, B. Ren, R. Harte, A. Hinrichs, Heather Trumbower, H. Clawson, Jennifer Hillman-Jackson, A. Zweig, Kayla E. Smith, Archana Thakkapallayil, G. Barber, R. Kuhn, D. Karolchik, L. Armengol, C. Bird, P. D. de Bakker, Andrew D. Kern, N. López-Bigas, Joel D Martin, B. Stranger, A. Woodroffe, Eugene Davydov, A. Dimas, E. Eyras, Ingileif B. Hallgrímsdóttir, J. Huppert, M. Zody, G. Abecasis, X. Estivill, G. Bouffard, Xiaobin Guan, Nancy F. Hansen, J. Idol, V. Maduro, Baishali Maskeri, Jennifer C Mcdowell, Morgan Park, Pamela J. Thomas, Alice C. Young, R. Blakesley, D. Muzny, E. Sodergren, D. Wheeler, K. Worley, Huaiyang Jiang, G. Weinstock, R. Gibbs, T. Graves, R. Fulton, E. Mardis, R. Wilson, M. Clamp, James A. Cuff, S. Gnerre, D. Jaffe, Jean L. Chang, K. Lindblad-Toh, E. Lander, M. Koriabine, M. Nefedov, K. Osoegawa, Y. Yoshinaga, B. Zhu, P. D. de Jong +310 moresemanticscholar +1 more sourceTRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi +18 morewiley +1 more sourceGenomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text
Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton +19 morewiley +1 more sourceTherapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim +18 morewiley +1 more source
