Results 21 to 30 of about 4,752 (146)

Improving gut virome comparisons using predicted phage host information

mSystems
The human gut virome is predominantly made up of bacteriophages (phages), viruses that infect bacteria. Metagenomic studies have revealed that phages in the gut are highly individual specific and dynamic.
Michael Shamash, Anshul Sinha, Corinne F. Maurice   +2 more
doaj   +3 more sources

A Previously Undescribed Highly Prevalent Phage Identified in a Danish Enteric Virome Catalog

mSystems, 2021
Gut viruses are important, yet often neglected, players in the complex human gut microbial ecosystem. Recently, the number of human gut virome studies has been increasing; however, we are still only scratching the surface of the immense viral diversity ...
Lore Van Espen, Emilie Glad Bak, Leen Beller, Lila Close, Ward Deboutte, Helene Bæk Juel, Trine Nielsen, Deniz Sinar, Lander De Coninck, Christine Frithioff-Bøjsøe, Cilius Esmann Fonvig, Suganya Jacobsen, Maria Kjærgaard, Maja Thiele, Anthony Fullam, Michael Kuhn, Jens-Christian Holm, Peer Bork, Aleksander Krag, Torben Hansen, Manimozhiyan Arumugam, Jelle Matthijnssens   +21 more
doaj   +3 more sources

Interpersonal variability of the human gut virome confounds disease signal detection in IBD. [PDF]

Commun Biol, 2023
AbstractViruses are increasingly recognised as important components of the human microbiome, fulfilling numerous ecological roles including bacterial predation, immune stimulation, genetic diversification, horizontal gene transfer, microbial interactions, and augmentation of metabolic functions.
Stockdale SR, Shkoporov AN, Khokhlova EV, Daly KM, McDonnell SA, O' Regan O, Nolan JA, Sutton TDS, Clooney AG, Ryan FJ, Sheehan D, Lavelle A, Draper LA, Shanahan F, Ross RP, Hill C.   +15 more
europepmc   +5 more sources

The human gut virome: form and function [PDF]

Emerging Topics in Life Sciences, 2017
Advances in next-generation sequencing technologies and the application of metagenomic approaches have fuelled an exponential increase in our understanding of the human gut microbiome. These approaches are now also illuminating features of the diverse and abundant collection of viruses (termed the virome) subsisting with the microbial ecosystems ...
Ogilvie, Lesley, Jones, Brian
openaire   +2 more sources

The gut virome in two indigenous populations from Malaysia

Scientific Reports, 2022
The human gut contains a complex microbiota dominated by bacteriophages but also containing other viruses and bacteria and fungi. There are a growing number of techniques for the extraction, sequencing, and analysis of the virome but currently no ...
Chuen Zhang Lee, Muhammad Zarul Hanifah Md Zoqratt, Maude E. Phipps, Jeremy J. Barr, Sunil K. Lal, Qasim Ayub, Sadequr Rahman   +6 more
doaj   +1 more source

Rapid evolution of the human gut virome [PDF]

Proceedings of the National Academy of Sciences, 2013
Humans are colonized by immense populations of viruses, which metagenomic analysis shows are mostly unique to each individual. To investigate the origin and evolution of the human gut virome, we analyzed the viral community of one adult individual over 2.5 y by extremely deep metagenomic sequencing (56 billion bases of purified ...
Samuel, Minot, Alexandra, Bryson, Christel, Chehoud, Gary D, Wu, James D, Lewis, Frederic D, Bushman   +5 more
openaire   +2 more sources

Varidnaviruses in the Human Gut: A Major Expansion of the Order Vinavirales

Viruses, 2022
Bacteriophages play key roles in the dynamics of the human microbiome. By far the most abundant components of the human gut virome are tailed bacteriophages of the realm Duplodnaviria, in particular, crAss-like phages. However, apart from duplodnaviruses,
Natalya Yutin, Mike Rayko, Dmitry Antipov, Pascal Mutz, Yuri I. Wolf, Mart Krupovic, Eugene V. Koonin   +6 more
doaj   +1 more source

Hypervariable loci in the human gut virome [PDF]

Proceedings of the National Academy of Sciences, 2012
Genetic variation is critical in microbial immune evasion and drug resistance, but variation has rarely been studied in complex heterogeneous communities such as the human microbiome. To begin to study natural variation, we analyzed DNA viruses present in the lower gastrointestinal tract of 12 human volunteers by determining 48 billion bases of viral ...
Samuel, Minot, Stephanie, Grunberg, Gary D, Wu, James D, Lewis, Frederic D, Bushman   +4 more
openaire   +2 more sources

Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19

Frontiers in Cellular and Infection Microbiology, 2021
Patients with Coronavirus Disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with respiratory issues and related symptoms, in addition to significantly affected digestive system ...
Zhen-Hua Lu, Hao-Wei Zhou, Hao-Wei Zhou, Wei-Kang Wu, Wei-Kang Wu, Ting Fu, Min Yan, Zhen He, Shi-Wei Sun, Shi-Wei Sun, Zhao-Hua Ji, Zhong-jun Shao   +11 more
doaj   +1 more source

Virome Sequencing of the Human Intestinal Mucosal–Luminal Interface

Frontiers in Cellular and Infection Microbiology, 2020
While the human gut virome has been increasingly explored in recent years, nearly all studies have been limited to fecal sampling. The mucosal–luminal interface has been established as a viable sample type for profiling the microbial biogeography of the ...
Austin Yan, James Butcher, David Mack, David Mack, Alain Stintzi   +4 more
doaj   +1 more source