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The human gut microbiota and virome: Potential therapeutic implications [PDF]
Digestive and Liver Disease, 2015 Human gut microbiota is a complex ecosystem with several functions integrated in the host organism (metabolic, immune, nutrients absorption, etc.). Human microbiota is composed by bacteria, yeasts, fungi and, last but not least, viruses, whose composition has not been completely described. According to previous evidence on pathogenic viruses, the human
Scarpellini, Emidio +5 more
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The human gut virome database [PDF]
, 2019 ABSTRACT The gut microbiome profoundly impacts human health and disease, but viruses that infect these microbes are likely also important. Problematically, viral sequences are often missed due to insufficient reference viral genomes. Here we (i) built a human gut virome database, GVD, from 648 viral particle metagenomes or microbial ...
Gregory, Ann C. +4 more
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Dynamic changes occur in the DNA gut virome of female cynomolgus macaques during aging
MicrobiologyOpen, 2021 Aging is a critical factor affecting physical health and disease in mammals. Emerging evidence indicates that aging may affect the gut bacteriome in cynomolgus macaques, but little is known about whether or how the gut virome changes with age.
Xunmin Tan +13 more
doaj +1 more source
The gut virome: the ‘missing link’ between gut bacteria and host immunity?
Therapeutic Advances in Gastroenterology, 2019 The human gut virome includes a diverse collection of viruses that infect our own cells as well as other commensal organisms, directly impacting on our well-being. Despite its predominance, the virome remains one of the least understood components of the
Indrani Mukhopadhya +4 more
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The Human Virome: Viral Metagenomics, Relations with Human Diseases, and Therapeutic Applications
Viruses, 2022 The human body is colonized by a wide range of microorganisms. The field of viromics has expanded since the first reports on the detection of viruses via metagenomic sequencing in 2002. With the continued development of reference materials and databases,
Geng-Hao Bai +3 more
doaj +1 more source
Viruses, 2019 The virome is comprised of endogenous retroviruses, eukaryotic viruses, and bacteriophages and is increasingly being recognized as an essential part of the human microbiome. The human virome is associated with Type-1 diabetes (T1D), Type-2 diabetes (T2D),
Tasha M. Santiago-Rodriguez +1 more
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iScience, 2021 Summary: Changes in the human gut microbiome are associated with obesity and metabolic syndrome, but the role of the gut virome in both diseases remains largely unknown. We characterized the gut dsDNA virome of 28 school-aged children with healthy normal-
Shirley Bikel +12 more
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Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity
Microbiome, 2021 Background Coronavirus disease 2019 (COVID-19) caused by the enveloped RNA virus SARS-CoV-2 primarily affects the respiratory and gastrointestinal tracts.
Tao Zuo +21 more
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Human virome: Implications in cancer
Heliyon, 2023 In recent years, the human virome has gained importance, especially after the SARS-CoV-2 pandemic, due to its possible involvement in autoimmune, inflammatory diseases, and cancer.
Rafael Tamayo-Trujillo +5 more
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Impact of HIV infection and integrase strand transfer inhibitors-based treatment on the gut virome
Scientific Reports, 2022 Viruses are the most abundant components of the human gut microbiome with a significant impact on health and disease. The effects of human immunodeficiency virus (HIV) infection on gut virome has been scarcely analysed.
Pablo Villoslada-Blanco +12 more
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