Results 111 to 120 of about 27,320,927 (309)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Combining analytical techniques, exposure assessment and biological effects for risk assessment of chemicals in food

, 2009
International audienceHumans today are exposed to a plethora of chemicals in food whether of anthropogenic or natural origin, and public-health agencies have developed risk-assessment methods to derive safe levels of exposure and to prevent adverse ...
Ramos-Bordajandi, L., Verger, Philippe, Dorne, J.L.C.M, Amzal, B., Ferrari, Philippe   +4 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Hydrochemical Controls, Source Apportionment, and Health Risks of Groundwater Nitrate in Rural Areas of the Huaibei Plain, China

Applied Sciences
Groundwater quality remains insufficiently characterized in the rural agriculture–residential interface of the Huaibei Plain, particularly with respect to nitrate (NO3−) occurrence, hydrochemical controls, source contributions, and population-specific ...
Lei Han, Jie Ma
doaj   +1 more source

Human health risk assessment of aluminium

, 2020
Mensen staan via verschillende bronnen bloot aan aluminium. Voorbeelden zijn voedsel, persoonlijke verzorgingsproducten, schoonmaakmiddelen, bodemdeeltjes en huisstof. Aluminium zit ook in sommige vaccins en medicijnen, zoals bepaalde maagzuurremmers.
Affourtit, F, Bakker, MI, Pronk, MEJ
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Environmental microbiome diversity and stability is a barrier to antimicrobial resistance gene accumulation

Communications Biology
When antimicrobial resistant bacteria (ARB) and genes (ARGs) reach novel habitats, they can become part of the habitat’s microbiome in the long term if they are able to overcome the habitat’s biotic resilience towards immigration.
Uli Klümper, Giulia Gionchetta, Elisa Catão, Xavier Bellanger, Irina Dielacher, Alan Xavier Elena, Peiju Fang, Sonia Galazka, Agata Goryluk-Salmonowicz, David Kneis, Uchechi Okoroafor, Elena Radu, Mateusz Szadziul, Edina Szekeres, Adela Teban-Man, Cristian Coman, Norbert Kreuzinger, Magdalena Popowska, Julia Vierheilig, Fiona Walsh, Markus Woegerbauer, Helmut Bürgmann, Christophe Merlin, Thomas Ulrich Berendonk   +23 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Risk Assessment Tools from the One Health Perspective: A Narrative Review [PDF]

Sandul Yasobant,1– 3 K Shruti Lekha,1 Deepak Saxena1,2 1Centre for One Health Education, Research & Development (COHERD), Indian Institute of Public Health Gandhinagar (IIPHG), Gandhinagar, Gujarat, India; 2School of Epidemiology & Public Health, Datta ...
Saxena D, Lekha KS, Yasobant S
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source