Results 91 to 100 of about 27,320,927 (309)
Frontiers in Public HealthChemical risk assessment can benefit from integrating informative biomarkers in human biomonitoring (HBM). Beyond exposure biomarkers, effect biomarkers inform on biological reactions in the body, potentially leading to adverse effects, while ...
Mathieu Gand +4 more
doaj +1 more source
, 2011 Before a site is considered contaminated, concentrations of chemicals, particularly natural elements, should be compared to data from local or regional surveys of background soil quality in uncontaminated areas, if data are available. On-site levels would be considered to be consistent with background where the maximum measured concentration of a COPC ...
openaire +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Public Comment on OMB Draft Risk Assessment Bulletin [PDF]
The OIRA draft Risk Assessment Bulletin has worthy intentions and has stimulated useful review and discussion.; Most previous major documents in the development of the risk assessment field have been cited and used appropriately.
Omenn, Gilbert S.
core
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Translation of Exposure and Epidemiology for Risk Assessment: A Shifting Paradigm
, 2020 Risk assessment is a well-established process used for various types of public health decision-making, such as setting chemical site clean-up levels, developing limits on exposures to chemicals in soil, water, air and food, and determining occupational ...
Joshua Naiman +2 more
core +1 more source
Discovering environmental health effects of transport scenarios through agent-based simulations
Environment InternationalUrban planning can help tackle environmental health issues. We demonstrate that agent-based simulation can discover unintended as well as intended environmental health effects and social inequalities of intervention scenarios.
Tabea S. Sonnenschein +4 more
doaj +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source