Results 71 to 80 of about 27,320,927 (309)

Pharmacokinetics of bisphenol A in humans following dermal administration

Environment International, 2020
Background: Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA following dermal exposure.
Alan F. Sasso, Ralph Pirow, Syam S. Andra, Rebecca Church, Rebecca M. Nachman, Susanne Linke, Dustin F. Kapraun, Shepherd H. Schurman, Manish Arora, Kristina A. Thayer, John R. Bucher, Linda S. Birnbaum   +11 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Human health risk assessment of potentially toxic elements (PTEs) from environmental matrices [PDF]

In assessing human health risk of potentially toxic elements (PTEs), it is not the concentration of PTEs in the environmental matrices that is of greatest concern but the fraction that is absorbed into the body via the exposure pathways.
Elom, Nwabueze
core  

Exploring the Quantitative Assessment of Spatial Risk in Response to Major Epidemic Disasters in Megacities: A Case Study of Qingdao

, 2023
With the global spread of various human-to-human epidemics, public health issues have become a focus of attention. Therefore, it is of great importance to improve the quantitative risk assessment of the construction of resilient cities in terms of ...
Qimeng Ren, Ming Sun, Sun, Ming, Ren, Qimeng   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dynamic Public Health Risk Assessment (DPHRA): advice for hospitals, care settings and Public Health Area Teams.

, 2023
Declaring an organisation wide outbreak of COVID or influenza at a healthcare setting should be based on an institutional risk assessment. A dynamic Public Health Risk Assessment at institutional level (hospital or care home) is undertaken by an ...
Health Protection Surveillance Centre (HPSC)
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Morphological variability of Escherichia coli colonizing human wounds: a case report

BMC Infectious Diseases
Background Escherichia coli, known for its adaptability, can cause diverse infections. Morphological variants, such as smooth and mucoid forms, correspond to different infection capabilities and antibiotic resistance profiles.
Xuejin Wang, Hanyu Wang, Jing Zhang, Yonglu Huang, Yongning Wu, Yang Wang, Rong Zhang   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source