Results 91 to 100 of about 655,601 (258)

TNF Pathway‐Mediated Tolerogenic T‐Cell Trajectory Driven by Allergen Immunotherapy

Allergy, EarlyView.
The study shows that AIT re‐establishes local immune equilibrium by restoring Th17/Treg balance, while circulating Th17 cells remain functionally impaired. The transition from pro‐inflammatory Th17 to regulatory T cell states during AIT identifies Tr17 cells as an intermediate cell population.
Helen S. Charles, Amr A. Gabr, Shu‐Hung Wang, Ulrich M. Zissler, Sonja Heine, Alexander Heldner, Sebastian Kotz, Lisa Pechtold, Lynn S. zur Bonsen, Dimitrii Pogorelov, Josephine Kau, Mirjam Plaschke, Miriam Hills, Ferdinand Guerth, Madlen Oelsner, Caspar Ohnmacht, Francesca Alessandrini, Simon Blank, Adam M. Chaker, Carsten B. Schmidt‐Weber, Constanze A. Jakwerth   +20 more
wiley   +1 more source

Case Report: Hydroa vacciniforme-like lymphoproliferative disorder, an EBV-associated disease, successfully treated with hematopoietic stem cell transplantation

Frontiers in Immunology
IntroductionThe hydroa-vacciniforme-like lymphoproliferative disorder (HVLD) is a rare NK/T-cell condition affecting children in Latin America and Asia.
Eduardo Liquidano-Perez, Eduardo Liquidano-Perez, Gibert Maza-Ramos, Marco Yamazaki-Nakashimada, Rodolfo Rodríguez-Jurado, Alfonso G. Ramírez Ristori, Juan Carlos Bustamante-Ogando, Mario Ernesto Cruz-Munoz, Arturo Gutierrez-Guerrero, Marimar Saez-de-Ocariz, Sara Espinosa-Padilla, Nideshda Ramirez-Uribe, Selma C. Scheffler-Mendoza   +12 more
doaj   +1 more source

Fatal Infection of a Pet Monkey with Human herpesvirus 1

Emerging Infectious Diseases, 2002
Concerns have been raised about pet monkeys as a potential threat to humans. We report the opposite situation, a danger to pets that arises from humans.
Hartwig P. Huemer, Clara Larcher, Thomas Czedik-Eysenberg, Norbert Nowotny, Martin Reifinger   +4 more
doaj   +1 more source

Deciphering the full spectrum of Castleman diseases based on a cohort of 700 patients in a western country

British Journal of Haematology, EarlyView.
The spectrum of Castleman diseases has expanded over the past three decades. The phenotype of the diseases varies not only among the three major types but also according to the patient ancestry. Summary Under the Castleman disease (CD) eponym, three distinct diseases sharing common pathological features have been described over time.
Eric Oksenhendler, Marion Malphettes, Véronique Meignin, David Boutboul, Lionel Galicier   +4 more
wiley   +1 more source

Protein chainmail variants in dsDNA viruses. [PDF]

, 2015
First discovered in bacteriophage HK97, biological chainmail is a highly stable system formed by concatenated protein rings. Each subunit of the ring contains the HK97-like fold, which is characterized by its submarine-like shape with a 5-stranded β ...
Chiou, Joshua, Zhou, Z Hong
core   +2 more sources

Perceived costs as drivers of wildlife management preferences in rural Tanzanian communities

Conservation Biology, EarlyView.
Abstract Effectively managing human–wildlife interactions is crucial for fostering coexistence on shared landscapes. Management options are most effective when aligned with the preferences of people directly affected by wildlife, yet little is known about how socioecological factors influence these preferences.
Christian Kiffner, Justin Raycraft, Reilly Becchina, Danielle Bettermann, Stephen Koester, Elana Kriegel, Kiana Lindsay, Edwin Maingo Ole, Emily Ramirez, Bryan Spizuco, Neil H. Carter   +10 more
wiley   +1 more source

Specific RNA structures in the 5′ untranslated region of the human cytomegalovirus major immediate early transcript are critical for efficient virus replication

mBio
Human cytomegalovirus (HCMV) requires the robust expression of two immediate early proteins, IE1 and IE2, immediately upon infection to suppress the antiviral response and promote viral gene expression.
Bekah Dickmander, Andrew Hale, Wes Sanders, Erik Lenarcic, Ben Ziehr, Nathaniel J. Moorman   +5 more
doaj   +1 more source

Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]

, 2015
Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty, Benjamin A. Keen, Bianchi, Bouché, Collins, Crute, Kaguni, Klinedinst, Klinedinst, Koonin, Marsden, Moss, Nigel C. Brissett, Rowen, Scherzinger, Sherman, Takechi, Thomas A. Guilliam   +17 more
core   +1 more source

Clinical and genetic characterization of intellectual disability

Developmental Medicine &Child Neurology, EarlyView.
This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara, Minna Kraatari‐Tiri, Jussi‐Pekka Tolonen, Marko Merikukka, IDGEN Study Group, Hannaleena Kokkonen, Teija Paakkola, Susanna Varis, Antti Dahl, Jarmo Körkkö, Jonna Komulainen‐Ebrahim, Jukka Moilanen, Johanna Uusimaa, Outi Kuismin, Elisa Rahikkala   +14 more
wiley   +1 more source

Two Waves of Specific B Cell Memory Immunoreconstruction Observed in Anti-HHV1–3 IgG Kinetics after Hematopoietic Stem Cell Transplantation

Biomedicines
Background: Humoral memory and specific antibody levels depend on the kind of antigen and individual immunofactors. The presence of IgM antibodies or a fourfold rise in specific IgG levels are generally accepted as diagnostic factors in the serology of ...
Przemyslaw Zdziarski, Andrzej Gamian
doaj   +1 more source