Results 111 to 120 of about 9,585,893 (249)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, Volume 13, Issue 61, 3 November 2026.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation

Frontiers in Immunology
IntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) cells,
Grant C. Weaver, Grant C. Weaver, Christine L. Schneider, Aniuska Becerra-Artiles, Kiera L. Clayton, Kiera L. Clayton, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +9 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Coreactivation of Human Herpesvirus 6 and Cytomegalovirus Is Associated With Worse Clinical Outcome in Critically Ill Adults. [PDF]

, 2015
Human herpesvirus 6 is associated with a variety of complications in immunocompromised patients, but no studies have systematically and comprehensively assessed the impact of human herpesvirus 6 reactivation, and its interaction with cytomegalovirus, in ...
Limaye, Ajit P, Huang, Meei-Li, Leisenring, Wendy M, Santo, Tracy K, Jerome, Keith R, Kirby, Katharine A, Hill, Joshua A, Boeckh, Michael, Lopez Roa, Paula   +8 more
core   +1 more source

Lumps, Bumps, and Diagnostic Stumps: A Case Report of IgG4‐Related Disease

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT IgG4‐related disease and idiopathic multicentric Castleman disease are rare conditions that can present with overlapping features, complicating diagnosis and delaying proper treatment.
Michael Miller, Jennifer Strouse, Nanmeng Yu, Carol Holman, Lindsay Moy   +4 more
wiley   +1 more source

Human Herpesvirus 6 Infection and Febrile Seizures

, 2010
Frequency and clinical characteristics of primary human herpesvirus 6 (HHV-6) infection in hospitalized children with febrile seizures (FS) were investigated at Aghia Sophia Children’s Hospital and Laiko General Hospital, Athens ...
J Gordon Millichap, J Gordon Millichap, Millichap, J. Gordon   +2 more
core   +1 more source

Empagliflozin Modulates Apoptosis and Autophagy Pathways in Lung Cancer Through Network Pharmacology and In Vitro Analysis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
An integrated computational and in vitro approach was used to investigate the anticancer activity of empagliflozin (EMPA) in A549 and HOP‐92 lung cancer cells and its interaction with hydroxychloroquine (HCQ). Network pharmacology identified 239 shared EMPA–lung cancer targets, while molecular docking predicted favorable interactions with ANXA8, SQSTM1/
Ola A. El‐Feky, Sara M. Hamouda, Manar Mohammed El Tabaa, Sally E. Abu‐Risha, Ahmed B. M. Mehany, Othman F. Abdelzaher, Samar A. El‐Adawy   +6 more
wiley   +1 more source

The host DHX29 RNA helicase regulates HCMV immediate-early protein synthesis

mBio
The DEAD-box helicase DHX29 plays a critical role in the translation of mRNAs containing complex RNA secondary structure in their 5′ untranslated regions (UTRs).
Erik M. Lenarcic, Nathaniel J. Moorman
doaj   +1 more source

The role of human herpesvirus 6, human herpesvirus 7, Epstein-Barr virus and cytomegalovirus in the aetiology of pityriasis rosea

, 2009
To identify the role of human herpesvirus 6 (HHV-6), HHV-7, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in the pathogenesis of pityriasis rosea (PR)
ATAK YÜCEL, AYŞEGÜL, Gurer, M. A., Canpolat Kirac, B., Bozdayi, G., Adisen, E., Aksakal, N., Fidan, IŞIL   +6 more
core   +1 more source

Can Unilateral Pityriasis Rosea be Considered a Form of Superimposed Lateralized Exanthem? [PDF]

Journal of Clinical and Diagnostic Research, 2017
Francesco Drago, Giulia Ciccarese, Aurora Parodi   +2 more
doaj   +1 more source