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Copy Number Heterogeneity, Large Origin Tandem Repeats, and Interspecies Recombination in Human Herpesvirus 6A (HHV-6A) and HHV-6B Reference Strains. [PDF]

open access: yesJ Virol, 2018
Greninger AL   +12 more
europepmc   +1 more source
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Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A

Journal of Neuroimmunology, 2005
Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chemokines, growth factors and their receptors by gene ...
Meeuwsen, S.   +6 more
openaire   +3 more sources

Human herpesvirus 6A U27 plays an essential role for the virus propagation

Microbiology and Immunology, 2020
AbstractHuman herpesvirus 6A (HHV‐6A) is a member of the genus Roseolovirus and the subfamily Betaherpesvirinae. It is similar to and human cytomegalovirus (HCMV). HHV‐6A encodes a 41 kDa nuclear phosphoprotein, U27, which acts as a processivity factor in the replication of the viral DNA.
Anna Lystia Poetranto   +5 more
openaire   +2 more sources

Familial case of inherited human herpesvirus 6A with phylogenetic assessment

Medicine of Extreme Situations, 2023
The paper reports a familial case of HHV-6A chromosomal integration being an important and relevant issue of genetics and medicine. The study was aimed to test the hypothesis of HHV-6A chromosomal integration and vertical transmission in patient with persistent virus detection during recurrent respiratory diseases and the asymptomatic period when there
OV Goleva   +8 more
openaire   +1 more source

Identification of stimuli that enhance human herpesvirus 6A (HHV-6A) replication and reconstitution

Journal of Virology
ABSTRACT Despite the availability of bacterial artificial chromosome (BAC) systems for human herpesvirus 6A (HHV-6A), reconstitution of infectious viruses is very challenging and time consuming. In this study, we developed approaches to improve the reconstitution process and enhance virus replication to overcome ...
Jana Reich   +3 more
openaire   +2 more sources

[The importance of telomeres in human herpesvirus-6A/B infections].

Medecine sciences : M/S, 2022
Herpesviruses are undisputed masters of disguise. The ability to become invisible to the immune system effectors is a complex process resting on a variety of stealth approaches. Among these, human herpesviruses-6A and -6B (HHV-6A/B) have developed the unique ability to integrate their genome within the ends of chromosomes allowing viral persistence in ...
Vanessa, Collin, Louis, Flamand
openaire   +1 more source

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