Results 1 to 10 of about 89,969 (25)
A Quantitative Analysis of Dynamic Mechanisms Regulating HIV Latency and Activation [PDF]
Prog. Biochem. Biophys. 2023,50(2):385-396, 2022 Objective: The reservoir of human immunodeficiency virus (HIV) latently infected cells is the major obstacle for eradication of acquired immunodeficiency syndrome (AIDS). Due to the noisy environment and multiple influencing factors in the organism, current dynamical models cannot reach a common understanding of the molecular mechanism of HIV latency ...
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Multiobjective optimization to a TB-HIV/AIDS coinfection optimal control problem [PDF]
Comput. Appl. Math. 37 (2018), no. 2, 2112--2128, 2017 We consider a recent coinfection model for Tuberculosis (TB), Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) proposed in [Discrete Contin. Dyn. Syst. 35 (2015), no. 9, 4639--4663]. We introduce and analyze a multiobjective formulation of an optimal control problem, where the two conflicting objectives are ...
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An in-host model of HIV incorporating latent infection and viral mutation [PDF]
Dynamical Systems, Differential Equations and Applications, AIMS
Proceedings, 2015 pp. 913-922, 2015 We construct a seven-component model of the in-host dynamics of the Human Immunodeficiency Virus Type-1 (i.e, HIV) that accounts for latent infection and the propensity of viral mutation. A dynamical analysis is conducted and a theorem is presented which characterizes the long time behavior of the model.
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Modeling TB-HIV syndemic and treatment [PDF]
J. Appl. Math. 2014 (2014), Art. ID 248407, 14 pp, 2014 Tuberculosis (TB) and human immunodeficiency virus (HIV) can be considered a deadly human syndemic. In this article, we formulate a model for TB and HIV transmission dynamics. The model considers both TB and acquired immune deficiency syndrome (AIDS) treatment for individuals with only one of the infectious diseases or both.
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On SICA models for HIV transmission [PDF]
Studies in Systems, Decision and Control 302 (2020), 155--179, 2020 We revisit the SICA (Susceptible-Infectious-Chronic-AIDS) mathematical model for transmission dynamics of the human immunodeficiency virus (HIV) with varying population size in a homogeneously mixing population. We consider SICA models given by systems of ordinary differential equations and some generalizations given by systems with fractional and ...
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Inspecting the interaction between HIV and the immune system through genetic turnover [PDF]
arXiv, 2022 Chronic infections of the human immunodeficiency virus (HIV) create a very complex co-evolutionary process, where the virus tries to escape the continuously adapting host immune system. Quantitative details of this process are largely unknown and could help in disease treatment and vaccine development.
arxiv
Discrete-Time System of an Intracellular Delayed HIV Model with CTL Immune Response [PDF]
, 2022 In [Math. Comput. Sci. 12 (2018), no. 2, 111--127], a delayed model describing the dynamics of the Human Immunodeficiency Virus (HIV) with Cytotoxic T Lymphocytes (CTL) immune response is investigated by Allali, Harroudi and Torres. Here, we propose a discrete-time version of that model, which includes four nonlinear difference equations describing the
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Estimation of HIV Burden through Bayesian Evidence Synthesis [PDF]
Statistical Science 2014, Vol. 29, No. 1, 9-17, 2014 Planning, implementation and evaluation of public health policies to control the human immunodeficiency virus (HIV) epidemic require regular monitoring of disease burden. This includes the proportion living with HIV, whether diagnosed or not, and the rate of new infections in the general population and in specific risk groups and regions. Estimation of
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The Effects of Latent Infection on the Dynamics of HIV [PDF]
Differential Equations and Dynamical Systems, 3, 2016, 2013 One way in which the human immunodeficiency virus (HIV-1) replicates within a host is by infecting activated CD4+ T-cells, which then produce additional copies of the virus. Even with the introduction of antiretroviral drug therapy, which has been very successful over the past decade, a large obstacle to the complete eradication of the virus is the ...
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Mixed models for longitudinal left-censored repeated measures [PDF]
Comput Methods Programs Biomed 74, 3 (06/2004) 255-60, 2007 Longitudinal studies could be complicated by left-censored repeated measures. For example, in Human Immunodeficiency Virus infection, there is a detection limit of the assay used to quantify the plasma viral load. Simple imputation of the limit of the detection or of half of this limit for left-censored measures biases estimations and their standard ...
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