Results 1 to 10 of about 110,150 (310)
Infection of human induced pluripotent stem cells by an oncogenic herpesvirus [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectiveAs one of the major human oncogenic viruses, Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is closely related to several cancers such as Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL). KSHV can infect a broad tropism of human primary
Jiaojiao Fan +4 more
doaj +2 more sources
Data in Brief, 2021 Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripotent ...
Anja Patricia Ramme +4 more
doaj +1 more source
Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies
Neural Regeneration Research, 2022 Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement therapies. Pluripotent stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected ...
Ignacio Rodriguez-Polo, Rüdiger Behr
doaj +1 more source
Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]
PLoS ONE, 2014 In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo +13 more
doaj +1 more source
A village in a dish model system for population-scale hiPSC studies
Nature Communications, 2023 The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions.
Drew R. Neavin +20 more
doaj +1 more source
Haematologica, 2015 Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn +16 more
doaj +1 more source
A stable chimeric fibroblast growth factor (FGF) can successfully replace basic FGF in human pluripotent stem cell culture. [PDF]
PLoS ONE, 2015 Fibroblast growth factors (FGFs) are essential for maintaining self-renewal in human embryonic stem cells and induced pluripotent stem cells. Recombinant basic FGF (bFGF or FGF2) is conventionally used to culture pluripotent stem cells; however, because ...
Yasuko Onuma +8 more
doaj +1 more source
Stem Cell Research & Therapy, 2017 Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta +13 more
doaj +1 more source
A novel -mutated human induced pluripotent stem cell model for understanding -mutated tumors
Tumor Biology, 2020 A missense mutation of the guanine nucleotide binding protein alpha stimulating activity polypeptide 1 ( GNAS ) gene, typically Arg201Cys or Arg201His (R201H/R201C), leads to constitutive activation of the Gsα-cyclic AMP (cAMP) signaling pathway that ...
Katsuhito Watanabe +5 more
doaj +1 more source
Haematologica, 2010 Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne +13 more
doaj +1 more source