Results 11 to 20 of about 110,150 (310)

Induced Pluripotent Stem Cells and Human Disease [PDF]

Cell Stem Cell, 2008
Two recent studies report the generation of induced pluripotent stem cells from patients presenting with a total of eleven different diseases (Park et al., 2008; Dimos et al., 2008). Future differentiation studies using these lines may offer insight on specific disease pathophysiology and aid the design of protective drug therapies.
Alan Colman
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Electrophysiological properties of human induced pluripotent stem cells

American Journal of Physiology-Cell Physiology, 2009
Human embryonic stem cells (hESCs) can self-renew while maintaining their pluripotency. Direct reprogramming of adult somatic cells to induced pluripotent stem cells (iPSCs) has been reported. Although hESCs and human iPSCs have been shown to share a number of similarities, such basic properties as the electrophysiology of iPSCs have not been explored.
Peng Jiang, Stephanie N. Rushing, Chi‐Wing Kong, Ji‐Dong Fu, Deborah K. Lieu, Camie W. Chan, Wenbin Deng, Ronald A. Li   +7 more
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Requirements for human‐induced pluripotent stem cells

Cell Proliferation, 2022
Abstract‘Requirements for Human‐Induced Pluripotent Stem Cells’ is the first set of guidelines on human‐induced pluripotent stem cells in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, and instructions for use, labeling, packaging ...
Ying Zhang, Jun Wei, Jiani Cao, Kehua Zhang, Yaojin Peng, Hongkui Deng, Jiuhong Kang, Guangjin Pan, Yong Zhang, Boqiang Fu, Shijun Hu, Jie Na, Yan Liu, Lei Wang, Lingmin Liang, Huanxin Zhu, Yu Zhang, Zi‐Bing Jin, Jie Hao, Aijin Ma, Tongbiao Zhao, Junying Yu   +21 more
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Generation of human androgenetic induced pluripotent stem cells [PDF]

Scientific Reports, 2020
AbstractIn humans, parthenogenesis and androgenesis occur naturally in mature cystic ovarian teratomas and androgenetic complete hydatidiform moles (CHM), respectively. Our previous study has reported human parthenogenetic induced pluripotent stem cells from ovarian teratoma–derived fibroblasts and screening of imprinted genes using genome-wide DNA ...
Kisung Ko, Han Sung Hwang, Natalia Tapia, Na Young Choi, Hans R. Schöler, Hans R. Schöler, Kinarm Ko, Soon Chul Myung, Gwang Jun Kim, Jin Seok Bang, Yo Seph Park, Minseong Lee   +11 more
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Modeling Disease with Human Inducible Pluripotent Stem Cells [PDF]

Annual Review of Pathology: Mechanisms of Disease, 2019
Understanding the physiopathology of disease remains an essential step in developing novel therapeutics. Although animal models have certainly contributed to advancing this enterprise, their limitation in modeling all the aspects of complex human disorders is one of the major challenges faced by the biomedical research field. Human induced pluripotent
Grandy, Rodrigo, Tomaz, Rute A, Vallier, Ludovic   +2 more
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Derivation and Characterization of human Induced Pluripotent Stem Cells

Acta Naturae, 2009
Cell biology is one of the most rapidly developing branches in modern biology. The most interesting stages in early embryonic development for cell biology are those when a large number of cells are pluripotent. Inner-cell mass of blastocyst can be cultivated in vitro, and these cells are called embryonic stem cells.
Maria V. Shutova, Alexandra N. Bogomazova, Maria A. Lagarkova, С. Л. Киселев   +3 more
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Transfecting and Nucleofecting Human Induced Pluripotent Stem Cells [PDF]

Journal of Visualized Experiments, 2011
Genetic modification is continuing to be an essential tool in studying stem cell biology and in setting forth potential clinical applications of human embryonic stem cells (HESCs). While improvements in several gene delivery methods have been described, transfection remains a capricious process for HESCs, and has not yet been reported in human induced ...
Papri Chatterjee, Yuri Cheung, Chee Liew
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Molecular Analyses of Human Induced Pluripotent Stem Cells and Embryonic Stem Cells [PDF]

Cell Stem Cell, 2010
Recent work from our group and others has argued that human induced pluripotent stem cells (hiPSCs) generated by the introduction of four viruses bearing reprogramming factors differ from human embryonic stem cells (hESCs) at the level of gene expression (Chin et al., 2009). Many of the differences seen were common across independent labs and, at least
Mark H. Chin, Matteo Pellegrini, Kathrin Plath, William E. Lowry   +3 more
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Differentiation of human induced pluripotent stem cells into erythroid cells [PDF]

Stem Cell Research & Therapy, 2020
AbstractDuring the last years, several strategies have been made to obtain mature erythrocytes or red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB-derived hematopoietic stem cells (HSC) are a limited source and in vitro large-scale expansion of RBC from HSC remains problematic.
Mohsen Ebrahimi, Mehdi Forouzesh, Setareh Raoufi, Mohammad Ramazii, Farhoodeh Ghaedrahmati, Maryam Farzaneh   +5 more
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The Bioethics of Human Pluripotent Stem Cells: Will Induced Pluripotent Stem Cells End the Debate? [PDF]

The Open Stem Cell Journal, 2010
The ethical debate surrounding human pluripotent stem (PS) cell research is mainly due to use of human embryonic stem (ES) cells. It has been suggested by many that human induced pluripotent stem (iPS) cells would end the debate due to their non-embryonic origin. This review examines the ethical issues surrounding the use of iPS cells and their ES cell
Julia C. Watt, Nao Kobayashi
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