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Chondrogenic Differentiation of Human-Induced Pluripotent Stem Cells
2022The generation of large quantities of genetically defined human chondrocytes remains a critical step for the development of tissue engineering strategies for cartilage regeneration and high-throughput drug screening. This protocol describes chondrogenic differentiation of human-induced pluripotent stem cells (hiPSCs), which can undergo genetic ...
Amanda R, Dicks +3 more
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Genetic Manipulation of Human Induced Pluripotent Stem Cells
Current Protocols in Stem Cell Biology, 2012AbstractHuman induced pluripotent stem cells (HIPSC) have tremendous value as a source of autologous cells for cellular transplantation in the treatment of degenerative diseases. The protocols described here address methods for large‐scale genetic modification of HIPSCs.
Angela, Wang, Chee Gee, Liew
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Human disease modeling with induced pluripotent stem cells
Current Opinion in Genetics & Development, 2012In the past few years, cellular programming, whereby virtually all human cell types, including those deep within the brain or internal organs, can potentially be produced and propagated indefinitely in culture, has opened the door to a new type of disease modeling.
Alan, Trounson +2 more
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Kidney regeneration from human induced pluripotent stem cells
Current Opinion in Organ Transplantation, 2015Human induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are potential unlimited cell sources for renal cells in regenerative medicine. This review highlights recent advance in the directed differentiation of human iPSCs into kidney lineages and discusses the remaining challenges to generate functional or mature renal cells from ...
Shin-Ichi, Mae, Kenji, Osafune
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Human induced pluripotent stem cells: A disruptive innovation
Current Research in Translational Medicine, 2016This year (2016) will mark the 10th anniversary of the discovery of induced pluripotent stem cells (iPSCs). The finding that the transient expression of four transcription factors can radically remodel the epigenome, transcriptome and metabolome of differentiated cells and reprogram them into pluripotent stem cells has been a major and groundbreaking ...
J, De Vos +4 more
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Translational Prospects for Human Induced Pluripotent Stem Cells
Regenerative Medicine, 2010The pace of research on human induced pluripotent stem (iPS) cells is frantic worldwide, based on the enormous therapeutic potential of patient-specific pluripotent cells free of the ethical and political issues that plagued human embryonic stem cell research.
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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Science, 2007Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors ( OCT4, SOX2, NANOG , and LIN28 ) are sufficient to reprogram human ...
Junying, Yu +11 more
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Modelling Chemotherapy-induced Cardiotoxicity by Human Pluripotent Stem Cells
Current Drug Targets, 2017Novel antineoplastic therapies have greatly improved cancer survival; nevertheless they are bringing in new forms of cardiomyopathy, that can often limit proper cancer treatments. Novel cardioprotective therapies are therefore needed, for improving clinical outcomes in cancer patients.
Madonna, Rosalinda +5 more
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Human Embryonic Stem Cells vs Human Induced Pluripotent Stem Cells for Cardiac Repair
Canadian Journal of Cardiology, 2014Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) have the capacity to differentiate into any specialized cell type, including cardiomyocytes. Therefore, hESC-derived and hiPSC-derived cardiomyocytes (hESC-CMs and hiPSC-CMs, respectively) offer great potential for cardiac regenerative medicine. Unlike some organs, the
Lili, Barad +4 more
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Thalidomide induces apoptosis in undifferentiated human induced pluripotent stem cells
In Vitro Cellular & Developmental Biology - Animal, 2017Thalidomide, which was formerly available commercially to control the symptoms of morning sickness, is a strong teratogen that causes fetal abnormalities. However, the mechanism of thalidomide teratogenicity is not fully understood; thalidomide toxicity is not apparent in rodents, and the use of human embryos is ethically and technically untenable.
Saoko Tachikawa +3 more
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