Results 21 to 30 of about 197,033 (249)

Neutrophil differentiation from human‐induced pluripotent stem cells [PDF]

Journal of Cellular Physiology, 2011
AbstractInduced pluripotent stem (iPS) cells are of potential value not only for regenerative medicine, but also for disease investigation. The present study describes the development of a neutrophil differentiation system from human iPS cells (hiPSCs) and the analysis of neutrophil function and differentiation. The culture system used consisted of the
Tatsuya, Morishima, Ken-ichiro, Watanabe, Akira, Niwa, Hisanori, Fujino, Hiroshi, Matsubara, Souichi, Adachi, Hirofumi, Suemori, Tatsutoshi, Nakahata, Toshio, Heike   +8 more
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Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
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Modeling Disease with Human Inducible Pluripotent Stem Cells [PDF]

Annual Review of Pathology: Mechanisms of Disease, 2019
Understanding the physiopathology of disease remains an essential step in developing novel therapeutics. Although animal models have certainly contributed to advancing this enterprise, their limitation in modeling all the aspects of complex human disorders is one of the major challenges faced by the biomedical research field. Human induced pluripotent
Grandy, Rodrigo, Tomaz, Rute A, Vallier, Ludovic   +2 more
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Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin

Haematologica, 2015
Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn, Katharina Klich, Marcos J. Arauzo-Bravo, Martina Radstaak, Simeon Santourlidis, Foued Ghanjati, Teja F. Radke, Olympia E. Psathaki, Gunnar Hargus, Jan Kramer, Martin Einhaus, Jeong Beom Kim, Gesine Kögler, Peter Wernet, Hans R. Schöler, Peter Schlenke, Holm Zaehres   +16 more
doaj   +1 more source

A novel -mutated human induced pluripotent stem cell model for understanding -mutated tumors

Tumor Biology, 2020
A missense mutation of the guanine nucleotide binding protein alpha stimulating activity polypeptide 1 ( GNAS ) gene, typically Arg201Cys or Arg201His (R201H/R201C), leads to constitutive activation of the Gsα-cyclic AMP (cAMP) signaling pathway that ...
Katsuhito Watanabe, Takashi Nakamura, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma   +5 more
doaj   +1 more source

Induced Pluripotent Stem Cells and Human Disease [PDF]

Cell Stem Cell, 2008
Two recent studies report the generation of induced pluripotent stem cells from patients presenting with a total of eleven different diseases (Park et al., 2008; Dimos et al., 2008). Future differentiation studies using these lines may offer insight on specific disease pathophysiology and aid the design of protective drug therapies.
openaire   +2 more sources

Transfecting and Nucleofecting Human Induced Pluripotent Stem Cells [PDF]

Journal of Visualized Experiments, 2011
Genetic modification is continuing to be an essential tool in studying stem cell biology and in setting forth potential clinical applications of human embryonic stem cells (HESCs). While improvements in several gene delivery methods have been described, transfection remains a capricious process for HESCs, and has not yet been reported in human induced ...
Chatterjee, Papri, Cheung, Yuri, Liew, Chee   +2 more
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Generation of human androgenetic induced pluripotent stem cells [PDF]

Scientific Reports, 2020
AbstractIn humans, parthenogenesis and androgenesis occur naturally in mature cystic ovarian teratomas and androgenetic complete hydatidiform moles (CHM), respectively. Our previous study has reported human parthenogenetic induced pluripotent stem cells from ovarian teratoma–derived fibroblasts and screening of imprinted genes using genome-wide DNA ...
Na Young Choi, Jin Seok Bang, Yo Seph Park, Minseong Lee, Han Sung Hwang, Kisung Ko, Soon Chul Myung, Natalia Tapia, Hans R. Schöler, Gwang Jun Kim, Kinarm Ko   +10 more
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Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

Haematologica, 2010
Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne, Ladan Kobari, Christelle Mazurier, Philippe Tropel, Marie-Catherine Giarratana, Isabelle Zanella-Cleon, Laurent Kiger, Marie Wattenhofer-Donzé, Hélène Puccio, Nicolas Hebert, Alain Francina, Georges Andreu, Stéphane Viville, Luc Douay   +13 more
doaj   +1 more source

GMP-compatible and xeno-free cultivation of mesenchymal progenitors derived from human-induced pluripotent stem cells

Stem Cell Research & Therapy, 2019
Background Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity.
Madison McGrath, Edmund Tam, Martina Sladkova, Athbah AlManaie, Matthew Zimmer, Giuseppe Maria de Peppo   +5 more
doaj   +1 more source