Results 31 to 40 of about 110,150 (310)

Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Regenerative Therapy, 2017
Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno, Keiko Hiemori, Kazunari Hirayasu, Nagako Sougawa, Masakazu Fukuda, Masaki Warashina, Makoto Amano, Taku Funakoshi, Yoshifusa Sadamura, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Tomoko Shofuda, Miho Sumida, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano, Yasuko Onuma, Yuzuru Ito, Makoto Asashima, Jun Hirabayashi   +20 more
doaj   +1 more source

Human Induced Pluripotent Stem Cells in Hepatology

The American Journal of Pathology, 2014
The discovery of the wide plasticity of most cell types means that it is now possible to produce virtually any cell type in vitro. This concept, developed because of the possibility of reprogramming somatic cells toward induced pluripotent stem cells, provides the opportunity to produce specialized cells that harbor multiple phenotypical traits, thus ...
Sabine Gerbal-Chaloin, Sabine Gerbal-Chaloin, Benoite Champon, Benoite Champon, Benoite Champon, Amandine Caillaud, Amandine Caillaud, Amandine Caillaud, Karim Si-Tayeb, Karim Si-Tayeb, Karim Si-Tayeb, Natalie Funakoshi, Natalie Funakoshi, Claire Gondeau, Claire Gondeau   +14 more
openaire   +5 more sources

Human Induced Pluripotent Stem Cells on Autologous Feeders

PLoS ONE, 2009
For therapeutic usage of induced Pluripotent Stem (iPS) cells, to accomplish xeno-free culture is critical. Previous reports have shown that human embryonic stem (ES) cells can be maintained in feeder-free condition. However, absence of feeder cells can be a hostile environment for pluripotent cells and often results in karyotype abnormalities. Instead
Kazutoshi Takahashi, Tomoko Ichisaka, Shinya Yamanaka, Midori Yokura, Megumi Narita   +4 more
openaire   +5 more sources

A Chemical Probe that Labels Human Pluripotent Stem Cells

Cell Reports, 2014
A small-molecule fluorescent probe specific for human pluripotent stem cells would serve as a useful tool for basic cell biology research and stem cell therapy. Screening of fluorescent chemical libraries with human induced pluripotent stem cells (iPSCs)
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi   +24 more
doaj   +1 more source

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

Haematologica, 2012
Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells ...
Ladan Kobari, Frank Yates, Noufissa Oudrhiri, Alain Francina, Laurent Kiger, Christelle Mazurier, Shaghayegh Rouzbeh, Wassim El-Nemer, Nicolas Hebert, Marie-Catherine Giarratana, Sabine François, Alain Chapel, Hélène Lapillonne, Dominique Luton, Annelise Bennaceur-Griscelli, Luc Douay   +15 more
doaj   +1 more source

Human induced pluripotent stem cells generated from a patient with a homozygous mutation in the Lyn kinase gene

Stem Cell Research, 2022
We have successfully generated induced pluripotent stem cells (iPSC) from dermal fibroblasts of the patient with a germline mutation in the coding region of the LYN kinase gene.
Rebecca Harper, Quan Yu, Yangtenyu Liu, Dan Yang, Jizhong Zou, Jeanette Beers, Adriana A. de Jesus Rasheed, Raphaela Goldbach-Mansky, Manfred Boehm, Guibin Chen   +9 more
doaj   +1 more source

MicroRNA Profiling of Human-Induced Pluripotent Stem Cells [PDF]

Stem Cells and Development, 2009
MicroRNAs (miRNAs) are a newly discovered endogenous class of small noncoding RNAs that play important posttranscriptional regulatory roles by targeting mRNAs for cleavage or translational repression. Accumulating evidence now supports the importance of miRNAs for human embryonic stem cell (hESC) self-renewal, pluripotency, and differentiation. However,
Atul J. Butte, Kitchener D. Wilson, Joseph C. Wu, Ning Sun, Fangjun Jia, Shivkumar Venkatasubrahmanyam   +5 more
openaire   +2 more sources

Is Human-induced Pluripotent Stem Cell the Best Optimal?

Chinese Medical Journal, 2018
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modeling, drug discovery, and cell therapy development.
Peng Liu, Yiyao Cui, Jie Kong, Jianyan Wen, Feng Wang   +4 more
openaire   +4 more sources

Human pluripotent stem cells in contemporary medicine

Исследования и практика в медицине, 2015
Human pluripotent stem cells (hPSCs) are capable of indefinite proliferation and can be differentiated into any cell type of the human body. Therefore, they are a promising source of cells for treatment of numerous degenerative diseases and injuries ...
S. A. Rodin
doaj   +1 more source

The quantitative proteomes of human‐induced pluripotent stem cells and embryonic stem cells

Molecular Systems Biology, 2011
Assessing relevant molecular differences between human-induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) is important, given that such differences may impact their potential therapeutic use. Controversy surrounds recent gene expression studies comparing hiPSCs and hESCs.
Munoz, J, Low, T.Y, Kok, Y.J, Chin, A, Frese, C.K, Ding, V, Choo, A, Heck, A.J.R   +7 more
openaire   +5 more sources