DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]
PLoS ONE, 2012 The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo +7 more
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SAGE Open Medicine, 2020 Objectives: To establish a straightforward single-cell passaging cultivation method that enables high-quality maintenance of human induced pluripotent stem cells without the appearance of karyotypic abnormalities or loss of pluripotency.
Estela Cruvinel +14 more
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Defining differentially methylated regions specific for the acquisition of pluripotency and maintenance in human pluripotent stem cells via microarray. [PDF]
PLoS ONE, 2014 Epigenetic regulation is critical for the maintenance of human pluripotent stem cells. It has been shown that pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells, appear to have a hypermethylated status compared with ...
WenYin He +9 more
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Regenerative strategies for kidney engineering [PDF]
, 2016 The kidney is the most important organ for water homeostasis and waste excretion. It performs several important physiological functions for homeostasis: it filters the metabolic waste out of circulation, regulates body fluid balances, and acts as an ...
Garreta, Elena +2 more
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CD157<sup>+</sup> vascular endothelial cells derived from human-induced pluripotent stem cells have high angiogenic potential. [PDF]
Inflamm RegenTakii A +7 more
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Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities [PDF]
, 2019 Three-dimensional (3D) printing of biological material, or 3D bioprinting, is a rapidly expanding field with interesting applications in tissue engineering and regenerative medicine. Bioprinters use cells and biocompatible materials as an ink (bioink) to
Rosa, Alessandro, Salaris, Federico
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MicroRNA Profiling of Human-Induced Pluripotent Stem Cells [PDF]
Stem Cells and Development, 2009 MicroRNAs (miRNAs) are a newly discovered endogenous class of small noncoding RNAs that play important posttranscriptional regulatory roles by targeting mRNAs for cleavage or translational repression. Accumulating evidence now supports the importance of miRNAs for human embryonic stem cell (hESC) self-renewal, pluripotency, and differentiation. However,
Kitchener D, Wilson +5 more
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Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia
Haematologica, 2014 Although β-thalassemia is one of the most common human genetic diseases, there is still no effective treatment other than bone marrow transplantation.
Guanheng Yang +7 more
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Improving single-cell cloning workflow for gene editing in human pluripotent stem cells [PDF]
, 2018 The availability of human pluripotent stem cells (hPSCs) and progress in genome engineering technology have altered the way we approach scientific research and drug development screens.
Chen, Yi-Hsien, Pruett-Miller, Shondra M
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Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells [PDF]
Circulation, 2009 Background— The ability to derive human induced pluripotent stem (hiPS) cell lines by reprogramming of adult fibroblasts with a set of transcription factors offers unique opportunities for basic and translational cardiovascular research.
Limor, Zwi +6 more
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