Results 61 to 70 of about 197,033 (249)
Human pluripotent stem cells as tools for high-throughput and high-content screening in drug discovery [PDF]
, 2015 A significant bottleneck in drug discovery is the lack of suitable models for sensitive, reliable, and rapid assessment of lead molecules in preclinical stages of drug discovery.
Allison, T.F. +4 more
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Induced pluripotent stem (iPS) cells from human fetal stem cells (hFSCs) [PDF]
Organogenesis, 2013 (1) Human embryonic stem (ES) cells are pluripotent but are difficult to be used for therapy because of immunological, oncological and ethical barriers. (2) Pluripotent cells exist in vivo, i.e., germ cells and epiblast cells but cannot be isolated without sacrificing the developing embryo. (3) Reprogramming to pluripotency is possible from adult cells
Valentina, Spinelli +2 more
openaire +2 more sources
Generation of Human Epidermis-Derived Mesenchymal Stem Cell-like Pluripotent Cells and their reprogramming in mouse chimeras [PDF]
, 2011 Stem cells can be derived from the embryo (embryonic stem cells, ESCs), from adult tissues (adult stem cells, ASCs), and by induction of fibroblasts (induced pluripotent stem cells, iPSs).
Bing Huang +21 more
core +1 more source
Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]
, 2016 Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P +9 more
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Stem Cell Reports, 2014 We describe the use of a characteristic blue fluorescence to identify and isolate pluripotent human embryonic stem cells and human-induced pluripotent stem cells.
Thangaselvam Muthusamy +4 more
doaj +1 more source
Induced pluripotent stem cell (iPSC) line (ZZUNEUi009-A) from a healthy female individual
Stem Cell Research, 2021 Induced pluripotent stem cells (iPSCs) can be used to generate different types of somatic cells in vitro and are a useful tool for investigating drug and disease mechanisms.
Mengduan Liu +8 more
doaj +1 more source
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
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HEXIM1 Induces Differentiation of Human Pluripotent Stem Cells
PLoS ONE, 2013 Hexamethylene bisacetamide inducible protein 1 (HEXIM1) is best known as the inhibitor of positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9)/cyclin T1. P-TEFb is an essential regulator for the transcriptional elongation by RNA polymerase II.
Ding, V. +7 more
openaire +4 more sources
Сибирский научный медицинский журнал, 2019 Stem cells are divided into embryonic and adult stem cells. The relevance of the use of stem cells in clinical practice has received new evidence in recent years however, the methods of obtaining stem cells for medical purposes cause ethical rejection ...
A. V. Korel, S. B. Kuznetsov
doaj +1 more source
Stem Cell Research, 2022 In this study, we report the generation of a novel human induced pluripotent stem cell (hiPSC) line from bone marrow mononuclear cells of a patient with multiple myeloma, using an integrative Sendai virus vector. This pluripotent cell line has been shown
Ji-Hyeon Hong +5 more
doaj +1 more source