Results 71 to 80 of about 110,150 (310)

Electrically Guiding Migration of Human Induced Pluripotent Stem Cells [PDF]

Stem Cell Reviews and Reports, 2011
A major road-block in stem cell therapy is the poor homing and integration of transplanted stem cells with the targeted host tissue. Human induced pluripotent stem (hiPS) cells are considered an excellent alternative to embryonic stem (ES) cells and we tested the feasibility of using small, physiological electric fields (EFs) to guide hiPS cells to ...
Qunli Zeng, Qunli Zeng, Jiaping Zhang, Yuesheng Huang, Ronald A. Li, Min Zhao, Marco Calafiore, Xiuzhen Zhang, Xiuzhen Zhang, Wenbin Deng   +9 more
openaire   +6 more sources

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source

Modeling Leukemia with Human Induced Pluripotent Stem Cells [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies.
openaire   +3 more sources

Somatic coding mutations in human induced pluripotent stem cells [PDF]

Nature, 2011
Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells into induced pluripotent stem cells. Although DNA factors are integrated during some reprogramming methods, it is unknown whether the genome remains unchanged at the single nucleotide level.
Gore, Athurva, Li, Zhe, Fung, Ho-Lim, Young, Jessica, Agarwal, Suneet, Antosiewicz-Bourget, Jessica, Canto, Isabel, Giorgetti, Alessandra, Israel, Mason A., Kiskinis, Evangelos, Lee, Je-Hyuk., Loh, Yuin-Han, Manos, Philip D., Montserrat, Núria, Panopoulos, Athanasia D., Ruiz, Sergio, Wilbert, Melissa L., Yu, Junying, Kirkness, Ewen F., Izpisúa Belmonte, Juan Carlos, Rossi, Derrick J., Thomson, James A., Eggan, Kevin, Daley, George Q., Goldstein, Lawrence S., Zhang, Kun   +25 more
openaire   +5 more sources

The Diverse Neuromuscular Spectrum of VPS13A Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective VPS13A disease (chorea‐acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease ...
Anne Buchberger, Evamaria Riedel, Marie Hackenberg, Alexander Mensch, Stefanie Beck‐Woedl, Joohyun Park, Tobias B. Haack, Bernhard Haslinger, Jan Kirschke, Holger Prokisch, Andreas Hermann, Christian Mawrin, Adrian Danek, Benedikt Schoser, Kevin Peikert, Marcus Deschauer, Isabell Cordts   +16 more
wiley   +1 more source

Heart regeneration with human pluripotent stem cells: Prospects and challenges

Bioactive Materials, 2020
Cardiovascular disease, ranging from congenital heart disease to adult myocardial infarction, is the leading cause of death worldwide. In pursuit of reliable cardiovascular regenerative medicine, human pluripotent stem cells (hPSCs), including human ...
Yuqian Jiang, Xiaojun Lance Lian
doaj   +1 more source

Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells [PDF]

Cell Stem Cell, 2010
Direct reprogramming of human fibroblasts to induced pluripotent stem cells (iPS) has been achieved by ectopic expression of defined transcription factors. Derivation of human fibroblasts however is a time consuming process and requires punch biopsies or isolation of patient foreskin.
Staerk, Judith, Dawlaty, Meelad M., Gao, Qing, Maetzel, Dorothea, Hanna, Jacob, Sommer, Cesar A., Mostoslavsky, Gustavo, Jaenisch, Rudolf   +7 more
openaire   +4 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Stem cell therapy for spinal cord injury: The use of oligodendrocytes and motor neurons derived from human embryonic stem cells

Translational Research in Anatomy, 2015
Over the past few years, the understanding of stem cells as a potential therapeutic source has significantly evolved, and the previous concept of irreparable neural injury is being reconsidered.
Nimer Adeeb, Aman Deep, Nicole Hose, Mona Rezaei, Salman Abbasi Fard, R. Shane Tubbs, Parham Yashar, Mark A. Liker, Babak Kateb, Martin M. Mortazavi   +9 more
doaj   +1 more source

Generation of an induced pluripotent stem cell line SYSUi-004-A from a child of microcephaly with TYW1 mutations

Stem Cell Research, 2020
We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents.
Chuanbo Sun, Pei Zhou, Simin Yuan, Ruirui Guo, Zhan Zhang, Qingyang Xu, Dingding Han, Lu He, Hongmei Tang, Kaishou Xu, Hao Hu, Na Li   +11 more
doaj   +1 more source