Results 21 to 30 of about 359,068 (363)

The Frequency of HLA-A, HLA-B, and HLA-DRB1 Alleles in Patients with Acute Lymphoblastic Leukemia in the Turkish Population: A Case-Control Study

Turkish Journal of Hematology, 2016
We studied the frequencies of human leukocyte antigen alleles (A, B, and DRB1) in 90 patients with acute lymphoblastic leukemia (ALL) and then compared them with 126 controls in this study. Although the frequencies of the A*03 allele, the DRB1*03 allele,
Türkan Patıroğlu, H. Haluk Akar
doaj   +1 more source

The viral transcription group determines the HLA class I cellular immune response against human respiratory syncytial virus [PDF]

, 2015
The cytotoxic T-lymphocyte-mediated killing of virus-infected cells requires previous recognition of short viral antigenic peptides bound to human leukocyte antigen class I molecules that are exposed on the surface of infected cells.
Akram, Alejandro Barriga, Anderson, Arie Admon, Ball, Bangham, Barik, Barnstable, Carolina Johnstone, Chella S. David, Cherrie, Collins, Croft, Daniel López, Del Val, Diez-Rivero, Eilon Barnea, Elena Lorente, Ellis, Eng, Falsey, Firat, Fortier, François A. Lemonnier, Goulder, Hall, Hammer, Han, Herberts, Homann, Infantes, Infantes, Ishihama, Ison, Juncker, Kastenmuller, Khare, Kondo, Lamb, Lorente, Lorente, Lorente, Lorente, López, McDermott, Meiring, Meyer, Parham, Pascolo, Pudney, Rammensee, Rohrlich, Sesma, Shastri, Shay, Susana Infantes, Tapia, Thompson, Tokusumi, Villadangos, Weinzierl, Wendt, York   +62 more
core   +2 more sources

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]

, 2017
Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L, Reed, Elaine F, Thomas, Kimberly A, Valenzuela, Nicole M   +3 more
core   +7 more sources

Improving Access to HLA-Matched Kidney Transplants for African American Patients

Frontiers in Immunology, 2022
IntroductionKidney transplants fail more often in Black than in non-Black (White, non-Black Hispanic, and Asian) recipients. We used the estimated physicochemical immunogenicity for polymorphic amino acids of donor/recipient HLAs to select weakly ...
Dulat Bekbolsynov, Beata Mierzejewska, Sadik Khuder, Obinna Ekwenna, Michael Rees, Michael Rees, Michael Rees, Robert C. Green, Stanislaw M. Stepkowski   +8 more
doaj   +1 more source

Accurate imputation of human leukocyte antigens with CookHLA [PDF]

Nature Communications, 2021
AbstractThe recent development of imputation methods enabled the prediction of human leukocyte antigen (HLA) alleles from intergenic SNP data, allowing studies to fine-map HLA for immune phenotypes. Here we report an accurate HLA imputation method, CookHLA, which has superior imputation accuracy compared to previous methods.
Soumya Raychaudhuri, Wanson Choi, Xiaoming Jia, Kunhee Kim, Kunhee Kim, Seungho Cook, Seungho Cook, Yang Luo, Buhm Han, Buhm Han, Buhm Han, Hyunjoon Lim   +11 more
openaire   +3 more sources

Genes predisposing to type 1 diabetes mellitus and pathophysiology: a narrative review [PDF]

arXiv, 2021
The possibility of targeting the causal genes along with the mechanisms of pathogenically complex diseases has led to numerous studies on the genetic etiology of some diseases. In particular, studies have added more genes to the list of type 1 diabetes mellitus (T1DM) suspect genes, necessitating an update for the interest of all stakeholders ...
arxiv  

Maternal and infant infections stimulate a rapid leukocyte response in breastmilk [PDF]

, 2013
Breastmilk protects infants against infections; however, specific responses of breastmilk immune factors to different infections of either the mother or the infant are not well understood. Here, we examined the baseline range of breastmilk leukocytes and
Filgueira, L, Hartmann, P, Hassiotou, F, Hepworth, A, Lai, C, Metzger, P, Trengove, N   +6 more
core   +3 more sources

Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes

Haematologica, 2012
Background Polymorphic differences between donor and recipient human leukocyte antigen class I molecules can result in graft-versus-host disease due to distinct peptide presentation. As part of the peptide-loading complex, tapasin plays an important role
Soumya Badrinath, Philippa Saunders, Trevor Huyton, Susanne Aufderbeck, Oliver Hiller, Rainer Blasczyk, Christina Bade-Doeding   +6 more
doaj   +1 more source

Evaluation of ascitic soluble human leukocyte antigen-G for distinguishing malignant ascites from benign ascites

Tumor Biology, 2017
The overexpression of soluble human leukocyte antigen-G is associated with malignant tumours. The purpose of our study was to detect soluble human leukocyte antigen-G concentrations in ascites and to evaluate the value of ascitic soluble human leukocyte ...
Juan Sun, Yan-Xiang Chang, Chun-Yan Niu
doaj   +1 more source