Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes [PDF]
Frontiers in Pharmacology, 2023 Eupalinolide A (EA; Z-configuration) and eupalinolide B (EB; E-configuration) are bioactive cis-trans isomers isolated from Eupatorii Lindleyani Herba that exert anti-inflammatory and antitumor effects.
Yingzi Li +8 more
doaj +2 more sources
Toxicology Reports, 2015 Terminalia arjuna is a tree having an extensive medicinal potential in cardiovascular disorders. Triterpenoids are mainly responsible for cardiovascular properties. Alcoholic and aqueous bark extracts of T.
Alice Varghese +3 more
doaj +2 more sources
Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions. [PDF]
Drug Metab Dispos, 2020 Human liver microsomes (HLM) and human liver S9 fractions (HLS9) are commonly used to study drug metabolism in vitro. However, a quantitative comparison of HLM and HLS9 proteomes is lacking, resulting in the arbitrary selection of one hepatic preparation
Wang X, He B, Shi J, Li Q, Zhu HJ.
europepmc +2 more sources
Tetrahydrofurofuranoid Lignans, Eudesmin, Fargesin, Epimagnolin A, Magnolin, and Yangambin Inhibit UDP-Glucuronosyltransferase 1A1 and 1A3 Activities in Human Liver Microsomes [PDF]
Pharmaceutics, 2021 Eudesmin, fargesin, epimagnolin A, magnolin, and yangambin are tetrahydrofurofuranoid lignans with various pharmacological activities found in Magnoliae Flos.
Ria Park +6 more
doaj +2 more sources
Evaluation of Herb–Drug Interaction Between Danshen and Rivaroxaban in Rat and Human Liver Microsomes [PDF]
Frontiers in Pharmacology, 2022 The combination of Salvia miltiorrhiza (Danshen) and rivaroxaban is a promising treatment option in clinical practice in China, but the herb–drug interaction between Danshen and rivaroxaban remains unclear.
Xu Wang +10 more
doaj +2 more sources
Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns [PDF]
Metabolites, 2023 Zotarolimus (ABT-578) is a sirolimus derivative that, like sirolimus and everolimus, is an inhibitor of cell growth via inhibition of the mechanistic target of rapamycin (mTOR).
Touraj Shokati +5 more
doaj +2 more sources
Human Liver Microsomal Metabolism of (+)-Discodermolide [PDF]
Journal of Natural Products, 2009 The polyketide natural product (+)-discodermolide is a potent microtubule stabilizer that has generated considerable interest in its synthetic, medicinal, and biological chemistry. It progressed to early clinical oncology trials, where it showed some efficacy in terms of disease stabilization but also some indications of causing pneumotoxicity ...
Yun, Fan +2 more
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Ethoxyresorufin O‐deethylation by human liver microsomes. [PDF]
British Journal of Clinical Pharmacology, 1986 As a substrate for human liver microsomes, ethoxyresorufin appears to be metabolised by a group of cytochrome P450 isoenzymes which are inducible by cigarette smoking. Kinetic studies in microsomes from four human livers indicate that only one enzyme component is involved over the full substrate range.
F M, Williams +4 more
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Biotransformation of (−)-Menthone by Human Liver Microsomes [PDF]
Bioscience, Biotechnology, and Biochemistry, 2006 The aim of the current study was to investigate the metabolism of (-)-menthone by liver microsomes of humans. (-)-Menthone (1) was metabolized to (+)-neomenthol (2) (3-reduction) and 7-hydroxymenthone (3) by human liver microsomes. The metabolites formed were analyzed on GC and GC-MS.
Mitsuo, Miyazawa, Kyousuke, Nakanishi
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Pharmacology Research & Perspectives, 2020 Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP ...
Ronald Kong +9 more
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