Results 31 to 40 of about 23,100 (164)

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism

Frontiers in Pharmacology
BackgroundEscitalopram (SCT), a highly effective and low-risk antidepressant, is widely used in the clinical treatment of depression. It undergoes two N-demethylation steps, producing its primary metabolites, S-demethylcitalopram (S-DCT) and S ...
Yifei Shen, Bingyi Yao, Yuanqing Guo, Yujia Yang, Chenmeizi Liang, Junze Huang, Yuanjin Zhang, Xin Wang   +7 more
doaj   +1 more source

In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics

Pharmaceutics, 2021
Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of Alzheimer’s disease. In general, donepezil is known as a safe and well-tolerated drug, and it was not associated with liver ...
Sin-Eun Kim, Hyung-Ju Seo, Yeojin Jeong, Gyung-Min Lee, Seung-Bae Ji, So-Young Park, Zhexue Wu, Sangkyu Lee, Sunghwan Kim, Kwang-Hyeon Liu   +9 more
doaj   +1 more source

CYP-Dependent Metabolism of PF9601N, A New Monoamine Oxidase-B Inhibitor, by C57BL / 6 Mouse and Human Liver Microsomes

Journal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine.
Stefania Dragoni, Giada Materozzi, Federica Pessina, Maria Frosini, José Luis Marco, Mercedes Unzeta, Giampietro Sgaragli, Massimo Valoti   +7 more
doaj   +1 more source

Metabolism of (+)- and (-)-Menthols by CYP2A6 in Human Liver Microsomes

Journal of Oleo Science, 2011
The in vitro metabolism of (+)-(1S,3S,4R) and (-)-(1R,3R,4S)-menthol enantiomers was examined by incubation with human liver microsomes, and the oxidative metabolites thus formed were analyzed using gas chromatography-mass spectrometry (GC-MS). The (+)- and (-)-menthols were found to be oxidized to the respective (+)-(1S,3S,4S)- and (-)-(1R,3R,4R ...
Miyazawa, Mitsuo, Marumoto, Shinsuke, Takahashi, Toshiyuki, Nakahashi, Hiroshi, Haigou, Risa, Nakanishi, Kyousuke   +5 more
openaire   +3 more sources

Hydroxymethylglutaryl CoA reductase and the modulation of microsomal cholesterol content by the nonspecific lipid transfer protein.

Journal of Lipid Research, 1984
The influence of membrane cholesterol content on 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase, EC 1.1.1.34) in rat liver microsomes was investigated.
G P van Heusden, K W Wirtz
doaj   +1 more source

A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm

Environment International
The chlorinated paraffin (CP) monomer 1,2,5,6,9,10-Hexachlorodecane (CP-4) was subjected to in vitro biotransformation using human and carp liver microsomes.
Liujun Chen, Caiming Tang, Zhiqiang Yu, Yanhong Zeng, Bixian Mai, Xiaojun Luo   +5 more
doaj   +1 more source

An integrated study for the utilization of anthraquinone compounds extract “Heshouwu” In vivo and their comparative metabolism in liver microsomes using UPLC-ESI-Q-TOF/MSn

World Journal of Traditional Chinese Medicine, 2018
Objective: Anthraquinone (AQ), a major bioactive component of the traditional Chinese medicine HeShouWu, has widespread applications in industry and medicine.
Sha Chen, Hong-Yu Ma, Zhe Deng, Jun Zhang, Jin-Tang Cheng, Chang Chen, An Liu   +6 more
doaj   +1 more source

Inhibition of human liver microsomal CYP by nateglinide

Journal of Pharmacy and Pharmacology, 2010
AbstractObjectivesNateglinide is metabolized by CYP2C9 and CYP3A4, therefore drug–drug interactions through cytochrome P450 (CYP) inhibition may occur. In this study, we examined the inhibitory effects of nateglinide and its major metabolite N-[trans-4-(1-hydroxy-1-methylethyl)-cyclohexanecarbonyl]-d-phenylalanine (M1) on various CYP isoforms in human ...
Toshiyuki, Takanohashi, Satoru, Kubo, Akira, Nakayama, Ryuichi, Mihara, Masahiro, Hayashi   +4 more
openaire   +2 more sources

In Vitro Metabolism and In Vivo Pharmacokinetics Profiles of Hydroxy-α-Sanshool

Toxics
Hydroxy-α-sanshool (HAS) is the predominant active compound in Zanthoxylum bungeanum Maxim (ZBM). Our present work was aimed to explore the in vitro metabolism characteristics, and in vivo pharmacokinetic (PK) profile of HAS.
Jie Meng, Die Qian, Ruo-Lan Li, Wei Peng, Li Ai   +4 more
doaj   +1 more source

Absorption and Metabolism Characteristics of Triptolide as Determined by a Sensitive and Reliable LC-MS/MS Method

Molecules, 2015
In this research, a sensitive and reliable LC-MS/MS method was developed and applied to determine the concentration of triptolide in rat plasma, microsomes, and cell incubation media. The absolute oral bioavailability of triptolide is 63.9% at a dose of
Xiaomei Gong, Yan Chen, Yi Wu
doaj   +1 more source