Results 51 to 60 of about 23,100 (164)

Metabolic Stability and Metabolite Characterization of Capilliposide B and Capilliposide C by LC–QTRAP–MS/MS

Pharmaceutics, 2018
Capilliposide B (LC-B) and Capilliposide C (LC-C), two new triterpenoid saponins extracted from Lysimachia capillipes Hemsl, exhibit potential anticancer activity both in vitro and in vivo. However, their metabolic process remains unclear. In this study,
Zhongzhe Cheng, Xing Zhou, Zhifeng Du, Wenyi Li, Bingying Hu, Jingkui Tian, Lin Zhang, Jiangeng Huang, Hongliang Jiang   +8 more
doaj   +1 more source

Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites

Toxicology Reports, 2015
Qualitative trapping profile of reactive metabolites arising from six structurally different compounds was tested with three different d-peptide isomers (Peptide 1, gly–tyr–pro–cys–pro–his-pro; Peptide 2, gly–tyr–pro–ala–pro–his–pro; Peptide 3, gly–tyr ...
Jaana E. Laine, Merja R. Häkkinen, Seppo Auriola, Risto O. Juvonen, Markku Pasanen   +4 more
doaj   +1 more source

Inhibition of cytochrome P450 enzymes by thymoquinone in human liver microsomes

Saudi Pharmaceutical Journal, 2018
The aim of the present study was to investigate the potential effect of thymoquinone (TQ) on the metabolic activity of four major drug metabolizing enzymes in human liver microsomes, namely cytochrome P450 (CYP) 1A2, CYP2C9, CYP2D6 and CYP3A4.
Ahmed A. Albassam, Abdul Ahad, Abdullah Alsultan, Fahad I. Al-Jenoobi   +3 more
doaj   +1 more source

Human liver microsomal oxidation of .DELTA.8-tetrahydrocannabinol.

Chemical and Pharmaceutical Bulletin, 1983
Human Liver microsomal oxidation products of Δ8-tetrahydrocannabinol (THC) were isolated and identified by thin-layer chromatography, gas chromatography and gas chromatography-mass spectrometry. As the results, five monohydroxylated metabolites including 11-hydroxy-Δ8-THC, and 8β, 9α-dihydroxyhexahydrocannabinol were identified as trimethyl-silyl ...
Yamamoto, Ikuo, Narimatsu, Shizuo, Watanabe, Kazuhito, Shimonishi, Tatsuyuki, Yoshimura, Hidetoshi, Nagano, Taizo   +5 more
openaire   +3 more sources

Systematic Characterization of In Vitro and In Vivo Metabolic Pathways and Identification of Novel Biomarkers of 26 Synthetic Cannabinoids

Molecules
In recent years, the harms and abuse of synthetic cannabinoids (SCs) have attracted extensive attention in society. Their structures have been updated rapidly, which brings great challenges for continuous detection and drug identification.
Yudie Ning, Tao Wang, Xiao Yang, Fang Guo, Yingwen Xu, Yuan Zhang, Kaile Wang, Meng Hu, Zhe Chen, Zhiwen Wei, Keming Yun   +10 more
doaj   +1 more source

In vitro metabolism of 20(R)-25-methoxyl-dammarane-3, 12, 20-triol from Panax notoginseng in human, monkey, dog, rat, and mouse liver microsomes.

PLoS ONE, 2014
The present study characterized in vitro metabolites of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(R)-25-OCH3-PPD) in mouse, rat, dog, monkey and human liver microsomes.
Xiangrong Zhang, Ji Zhang, Wei Li, Li Liu, Baoshan Sun, Zhenghong Guo, Caihong Shi, Yuqing Zhao   +7 more
doaj   +1 more source

Effect of Benidipine on Simvastatin Metabolism in Human Liver Microsomes

Drug Metabolism and Pharmacokinetics, 2007
Benidipine, which is a calcium channel blocker that has clinical advantages in the treatment of hypertension, is metabolized by CYP3A4 in humans. The effect of benidipine on the metabolism of simvastatin by human liver microsomes was investigated in order to predict the potential of in vivo drug-drug interactions between benidipine and other substrates
SUGIYAMA, Yuka, MIMURA, Nobuhito, KUWABARA, Takashi, KOBAYASHI, Hiroyuki, USHIKI, Junko, FUSE, Eiichi   +5 more
openaire   +2 more sources

Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman

Acute Medicine & Surgery
Aim The overdose of caffeine, a cytochrome P450 1A2 probe, in young women has become a problem. The aim of this study was to evaluate possible drug interactions between intentionally overdosed caffeine (12 g) and oral contraceptive doses of ethinyl ...
Koichiro Adachi, Maki Murata, Akiyoshi Inada, Takeyori Morimoto, Makiko Shimizu, Satoru Beppu, Hiroshi Yamazaki   +6 more
doaj   +1 more source

Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac

Molecules
Background: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare, Shalom Emmanuel, Ting Du, Huan Xie, Dong Liang, Song Gao   +5 more
doaj   +1 more source

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Canadian Journal of Gastroenterology and Hepatology, 2018
Biliary obstruction, a severe cholestatic complication, causes accumulation of toxic bile acids (BAs) in liver cells. Glucuronidation, catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, detoxifies cholestatic BAs. Using liquid chromatography coupled
Martin Perreault, Ewa Wunsch, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Guy G. Poirier, Piotr Milkiewicz, Olivier Barbier   +8 more
doaj   +1 more source