Results 51 to 60 of about 50,120 (254)
In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]
, 2011 Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Ekstrand, Bo +2 more
core +1 more source
Inhibition of human liver microsomal CYP by nateglinide
Journal of Pharmacy and Pharmacology, 2010 AbstractObjectivesNateglinide is metabolized by CYP2C9 and CYP3A4, therefore drug–drug interactions through cytochrome P450 (CYP) inhibition may occur. In this study, we examined the inhibitory effects of nateglinide and its major metabolite N-[trans-4-(1-hydroxy-1-methylethyl)-cyclohexanecarbonyl]-d-phenylalanine (M1) on various CYP isoforms in human ...
Toshiyuki, Takanohashi +4 more
openaire +2 more sources
In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics
Pharmaceutics, 2021 Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of Alzheimer’s disease. In general, donepezil is known as a safe and well-tolerated drug, and it was not associated with liver ...
Sin-Eun Kim +9 more
doaj +1 more source
Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]
, 2019 Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska +7 more
core +1 more source
Frontiers in PharmacologyBackgroundEscitalopram (SCT), a highly effective and low-risk antidepressant, is widely used in the clinical treatment of depression. It undergoes two N-demethylation steps, producing its primary metabolites, S-demethylcitalopram (S-DCT) and S ...
Yifei Shen +7 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2007 Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine.
Stefania Dragoni +7 more
doaj +1 more source
Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]
, 2016 This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed +4 more
core +1 more source
Human liver microsomal glutathione transferase [PDF]
FEBS Letters, 1993 Human liver microsomal glutathione transferase displays the following glutathione peroxidase/transferase activities: dilinoleoylphosphatidylcholine hydroperoxide (0.03 and 0.17 · mg, unactivated and N‐ethylmaleimide‐activated enzyme, respectively), linoleic acid hydroperoxide (0.09 and 0.15 · mg), cumene hydroperoxide (0.04 and 3 · mg), methyl ...
Mosialou, E. +6 more
openaire +2 more sources
Flavin-containing monooxygenases: mutations, disease and drug response [PDF]
, 2008 NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Pharmacological Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Phillips, IR, Shephard, EA
core +1 more source
Human liver microsomal oxidation of .DELTA.8-tetrahydrocannabinol.
Chemical and Pharmaceutical Bulletin, 1983 Human Liver microsomal oxidation products of Δ8-tetrahydrocannabinol (THC) were isolated and identified by thin-layer chromatography, gas chromatography and gas chromatography-mass spectrometry. As the results, five monohydroxylated metabolites including 11-hydroxy-Δ8-THC, and 8β, 9α-dihydroxyhexahydrocannabinol were identified as trimethyl-silyl ...
I, Yamamoto +5 more
openaire +3 more sources