Results 61 to 70 of about 23,100 (164)

Metabolic Profile Analysis of Designer Benzodiazepine Etizolam in Zebrafish and Human Liver Microsomes. [PDF]

Metabolites, 2023
Jie Z, Qin S, Zhang W, Wang J, Lu J, Qin G, Hou X, Xu P.   +7 more
europepmc   +1 more source

Electrochemical simulation of psychotropic drug metabolism compared to in vivo processes using liquid chromatography and mass spectrometry

Frontiers in Pharmacology
IntroductionPsychotropic drugs strongly affect the human psyche through their ability to modulate the neurotransmitter activity and to treat mental disorders and diseases. Monitoring of psychotropic drugs in clinical studies is significant.
Paulina Jerszyńska, Małgorzata Szultka-Młyńska, Małgorzata Szultka-Młyńska   +2 more
doaj   +1 more source

Corrigendum: Evaluation of herb-drug interaction between Danshen and rivaroxaban in rat and human liver microsomes. [PDF]

Front Pharmacol, 2022
Wang X, Fa J, Zhang Y, Huang S, Liu J, Gao J, Xing L, Liu Z, Wang X.   +8 more
europepmc   +1 more source

Impact of metabolic enzyme activity variability on dabrafenib disposition

Frontiers in Pharmacology
IntroductionThe systemic exposure of dabrafenib correlates with its adverse drug reactions. A thorough understanding of its pharmacokinetic profile is crucial for precise clinical application.MethodsAn optimized liver microsomal incubation system was ...
Shi-yu Wang, Shi-yu Wang, Qing Chen, Zhong-xi Chen, Jing Chen, Jing Yuan, Li-shang Dai, Lian-guo Chen, Xiao-dan Zhang, Xiao-dan Zhang   +9 more
doaj   +1 more source

Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity. [PDF]

BMC Complement Med Ther, 2022
Zhou J, Qian X, Zhou Y, Xiong S, Ji S, Wang Y, Zhao P.   +6 more
europepmc   +1 more source

Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes. [PDF]

Molecules, 2022
Su S, Wu H, Zhou J, Yuan G, Wang H, Feng J.   +5 more
europepmc   +1 more source

Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method. [PDF]

Molecules, 2023
Attwa MW, AlRabiah H, Mostafa GAE, Bakheit AH, Kadi AA.   +4 more
europepmc   +1 more source

Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes. [PDF]

Metabolites, 2022
Xu S, Sun L, Ding D, Zhang X, Liu X, Zhan P.   +5 more
europepmc   +1 more source

In Vitro characterization of narciclasine: solubility, metabolic stability, and P-glycoprotein substrate status

Frontiers in Pharmacology
BackgroundNarciclasine has demonstrated anticancer activity at low nanomolar concentrations in various preclinical cancer models, but no clinical data in cancer patients are available. Although its biological activity and structure-activity relationships
Ravi Akkireddy, Ravi Akkireddy, In-Hyoung Yang, In-Hyoung Yang, Srinivas Lenkalapelly, Srinivas Lenkalapelly, Ganesh J. Kshirsagar, Ganesh J. Kshirsagar, Harry A. May, Harry A. May, Harry A. May, Min H. Kang, Min H. Kang   +12 more
doaj   +1 more source

Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation. [PDF]

Molecules, 2023
Attwa MW, AlRabiah H, Mostafa GAE, Kadi AA.   +3 more
europepmc   +1 more source