Results 21 to 30 of about 23,100 (164)
Pharmaceuticals, 2020 Phloretin, the major polyphenol compound in apples and apple products, is interesting because it shows beneficial effects on human health. It is mainly found as a form of glucoside, phlorizin. However, the metabolic pathway of phloretin in humans has not
Ngoc Anh Nguyen +9 more
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Pharmacology Research & Perspectives, 2022 UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of
Kaoru Kobayashi +9 more
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Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 Cells. [PDF]
PLoS ONE, 2014 Antifungal drug ketoconazole causes severe drug-drug interactions by influencing gene expression and catalytic activity of major drug-metabolizing enzyme cytochrome P450 CYP3A4.
Aneta Novotná +6 more
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Frontiers in Pharmacology, 2023 The SARS-CoV-2 pandemic requires a new therapeutic target for viral infection, and papain-like protease (Plpro) has been suggested as a druggable target.
Hyunki Cho +6 more
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Dataset from proteomic analysis of human liver, lung, kidney and intestine microsomes
Data in Brief, 2018 We provide detailed datasets from our analysis of proteins that are identified in human liver, lung, kidney and intestine microsomes by MS-based proteomics.
Wei Song, Longjiang Yu, Zhihong Peng
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Interspecies Variation in NCMN-O-Demethylation in Liver Microsomes from Various Species
Molecules, 2019 NCMN (N-(3-carboxy propyl)-4-methoxy-1,8-naphthalimide), a newly developed ratiometric two-photon fluorescent probe for human Cytochrome P450 1A (CYP1A), shows the best combination of specificity and reactivity for real-time detection of the enzymatic ...
Ziru Dai +8 more
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In Vitro Phase I Metabolism of CRV431, a Novel Oral Drug Candidate for Chronic Hepatitis B
Pharmaceutics, 2017 The cytochrome P450-mediated Phase I in vitro metabolism of CRV431 was studied using selective chemical inhibition and recombinant human enzymes. Additionally, the metabolic profile of CRV431 in human, rat, and monkey liver microsomes was investigated ...
Daniel J. Trepanier +2 more
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Simultaneous determination of 9 CYP450 enzymes in human liver microsomes using LC-MS/MS
Di-san junyi daxue xuebao, 2021 Objective To develop a liquid chromatography with tandem mass spectrometry (LC-MS/MS) to simultaneously detect the activities of 9 CYP450 enzymes in human liver microsomes in order to anticipate the possibility of drug-drug interactions.
SHI Zhongbo +5 more
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Journal of Lipid Research, 1998 In vitro techniques have been used to investigate the nature of microsomal cytochrome P450 involved in the metabolism of oleic acid, a physiological monounsaturated fatty acid. Like lauric acid, which is cur rently used as a model substrate of fatty acid
Fadi Adas +5 more
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Qualification of Human Liver Microsomes for Antibacterial Activity Screening of Drug Metabolites
Applied Microbiology, 2023 Microsomes are commonly used to perform in vitro drug metabolism, predominantly to form phase I drug metabolites. Pooled microsomes from multiple donors can contain microorganisms from underlying microbial diseases.
Navid Jubaer
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