Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry
Mass Spectrometry Reviews, Volume 45, Issue 2, Page 244-259, March/April 2026.ABSTRACT Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS.
Nicholas E. Manicke +2 more
wiley +1 more source
Impact of metabolic enzyme activity variability on dabrafenib disposition
Frontiers in PharmacologyIntroductionThe systemic exposure of dabrafenib correlates with its adverse drug reactions. A thorough understanding of its pharmacokinetic profile is crucial for precise clinical application.MethodsAn optimized liver microsomal incubation system was ...
Shi-yu Wang +9 more
doaj +1 more source
Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method. [PDF]
Molecules, 2023 Attwa MW +4 more
europepmc +1 more source
The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities
MedComm, Volume 7, Issue 3, March 2026.Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou +5 more
wiley +1 more source
Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation. [PDF]
Molecules, 2023 Attwa MW +3 more
europepmc +1 more source
Potential Drivers of Successful Biocontrol: A Perspective on Parasitoids
New Zealand Journal of Zoology, Volume 53, Issue 1, March 2026.Parasitoids are central to classical biological control, yet predicting their long‐term effectiveness post release remains challenging. In Aotearoa New Zealand, three Microctonus (Hymenoptera: Braconidae) species have been used against pest weevils, but key aspects of their biology remain poorly understood.
Meeran Hussain +3 more
wiley +1 more source
Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes. [PDF]
Metabolites, 2022 Xu S +5 more
europepmc +1 more source
New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov +16 more
wiley +1 more source
New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka +1 more
wiley +1 more source
Identification and cross-species comparison of in vitro phase I brevetoxin (BTX-2) metabolites in northern Gulf of Mexico fish and human liver microsomes by UHPLC-HRMS(/MS). [PDF]
Toxicon X, 2023 Gwinn JK +5 more
europepmc +1 more source