Results 31 to 40 of about 287,149 (254)
Inhibition of human liver microsomal CYP by nateglinide
Journal of Pharmacy and Pharmacology, 2010 AbstractObjectivesNateglinide is metabolized by CYP2C9 and CYP3A4, therefore drug–drug interactions through cytochrome P450 (CYP) inhibition may occur. In this study, we examined the inhibitory effects of nateglinide and its major metabolite N-[trans-4-(1-hydroxy-1-methylethyl)-cyclohexanecarbonyl]-d-phenylalanine (M1) on various CYP isoforms in human ...
Toshiyuki, Takanohashi +4 more
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Nonspecific binding of drugs to human liver microsomes [PDF]
British Journal of Clinical Pharmacology, 2000 Aims To characterize the nonspecific binding to human liver microsomes of drugs with varying physicochemical characteristics, and to develop a model for the effect of nonspecific binding on the in vitro kinetics of drug metabolism enzymes.Methods The extent of nonspecific binding to human liver microsomes of the acidic drugs caffeine, naproxen ...
J A, McLure, J O, Miners, D J, Birkett
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In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics
Pharmaceutics, 2021 Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of Alzheimer’s disease. In general, donepezil is known as a safe and well-tolerated drug, and it was not associated with liver ...
Sin-Eun Kim +9 more
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Frontiers in PharmacologyBackgroundEscitalopram (SCT), a highly effective and low-risk antidepressant, is widely used in the clinical treatment of depression. It undergoes two N-demethylation steps, producing its primary metabolites, S-demethylcitalopram (S-DCT) and S ...
Yifei Shen +7 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2007 Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine.
Stefania Dragoni +7 more
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Human liver microsomal glutathione transferase [PDF]
FEBS Letters, 1993 Human liver microsomal glutathione transferase displays the following glutathione peroxidase/transferase activities: dilinoleoylphosphatidylcholine hydroperoxide (0.03 and 0.17 · mg, unactivated and N‐ethylmaleimide‐activated enzyme, respectively), linoleic acid hydroperoxide (0.09 and 0.15 · mg), cumene hydroperoxide (0.04 and 3 · mg), methyl ...
Mosialou, E. +6 more
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Human liver microsomal oxidation of .DELTA.8-tetrahydrocannabinol.
Chemical and Pharmaceutical Bulletin, 1983 Human Liver microsomal oxidation products of Δ8-tetrahydrocannabinol (THC) were isolated and identified by thin-layer chromatography, gas chromatography and gas chromatography-mass spectrometry. As the results, five monohydroxylated metabolites including 11-hydroxy-Δ8-THC, and 8β, 9α-dihydroxyhexahydrocannabinol were identified as trimethyl-silyl ...
I, Yamamoto +5 more
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Journal of Lipid Research, 1984 The influence of membrane cholesterol content on 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase, EC 1.1.1.34) in rat liver microsomes was investigated.
G P van Heusden, K W Wirtz
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World Journal of Traditional Chinese Medicine, 2018 Objective: Anthraquinone (AQ), a major bioactive component of the traditional Chinese medicine HeShouWu, has widespread applications in industry and medicine.
Sha Chen +6 more
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Environment InternationalThe chlorinated paraffin (CP) monomer 1,2,5,6,9,10-Hexachlorodecane (CP-4) was subjected to in vitro biotransformation using human and carp liver microsomes.
Liujun Chen +5 more
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