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A Protocol for the Automatic Construction of Highly Curated Genome-Scale Models of Human Metabolism [PDF]
Bioengineering, 2023 Genome-scale metabolic models (GEMs) have emerged as a tool to understand human metabolism from a holistic perspective with high relevance in the study of many diseases and in the metabolic engineering of human cell lines.
Igor Marin de Mas +4 more
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The Large Scale Structure of Human Metabolism Reveals Resilience via Extensive Signaling Crosstalk [PDF]
Frontiers in Physiology, 2020 Metabolism is loosely defined as the set of physical and chemical interactions associated with the processes responsible for sustaining life. Two evident features arise whenever one looks at metabolism: first, metabolism is conformed as a very complex ...
Laura Gómez-Romero +3 more
doaj +2 more sources
SULFUR CONTAINING MINERAL WATER AS A DIETARY FACTOR CHALLENGING THE PHASE II DETOXIFICATION ENZYMES IN HUMAN INTESTINAL CELLS [PDF]
Journal of IMAB, 2022 Introduction: According to the scientific literature, sulfur contained in various foods and medicines is almost completely absorbed in the gastrointestinal tract.
Todorka Sokrateva +5 more
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Doxycycline alters metabolism and proliferation of human cell lines. [PDF]
, 2013 The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells-including inhibition of the mitochondrial ribosome-there have been few ...
Ahler, Ethan +7 more
core +11 more sources
iScience, 2021 Summary: Obesity is an important risk factor and a potential treatment target for hepatic steatosis. The maladaptation of hepatic mitochondrial flexibility plays a key role in the hepatic steatosis.
Yaqiong Li +9 more
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Human metabolic atlas: an online resource for human metabolism [PDF]
Database, 2015 Human tissue-specific genome-scale metabolic models (GEMs) provide comprehensive understanding of human metabolism, which is of great value to the biomedical research community. To make this kind of data easily accessible to the public, we have designed and deployed the human metabolic atlas (HMA) website (http://www.metabolicatlas.org).
Pornputtapong, Natapol +2 more
openaire +2 more sources
iScience, 2022 Summary: Intracellular and environmental cues result in heterogeneous cancer cell populations with different metabolic and migratory behaviors. Although glucose metabolism and epithelial-to-mesenchymal transition have previously been linked, we aim to ...
Samantha C. Schwager +8 more
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Metabolic Imaging in Humans [PDF]
Topics in Magnetic Resonance Imaging, 2016 Metabolic imaging enhances understanding of disease metabolisms and holds great potential as a measurement tool for evaluating disease prognosis and treatment effectiveness. Advancement of techniques, such as magnetic resonance spectroscopy, positron emission tomography, and mass spectrometry, allows for improved accuracy for quantification of ...
Taylor L, Fuss, Leo L, Cheng
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iScience, 2021 Summary: Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly.
Ming Wang +12 more
doaj +1 more source
Manganese metabolism in humans [PDF]
Frontiers in Bioscience, 2018 Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor for a variety of enzymes, including arginase, glutamine synthetase (GS), pyruvate carboxylase and Mn superoxide dismutase (Mn-SOD). Through these metalloproteins, Mn plays critically important roles in development, digestion, reproduction, antioxidant ...
Chen, Pan +2 more
openaire +2 more sources