Results 21 to 30 of about 2,261,504 (355)

Membrane transporters in a human genome-scale metabolic knowledgebase and their implications for disease

Frontiers in Physiology, 2014
Membrane transporters enable efficient cellular metabolism, aid in nutrient sensing, and have been associated with various diseases, such as obesity and cancer.
Swagatika eSahoo, Swagatika eSahoo, Maike Kathrin Aurich, Jon Johannes Jonsson, Ines eThiele, Ines eThiele   +5 more
doaj   +1 more source

Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host [PDF]

, 2019
A major gap in understanding infectious diseases is the lack of information about molecular interaction networks between pathogens and the human host.
Barnes, Stephen, Fortney, Kate R., Gao, Hongyu, Griesenauer, Brad, Janowicz, Diane M., Johnson, Paula, Liu, Yunlong, Spinola, Stanley M., Tran, Tuan M., Wilson, Landon S.   +9 more
core   +1 more source

Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women

Nutrition Journal, 2022
Background Intermittent fasting (IF), consisting of either a one-day (IF1) or two consecutive days (IF2) per week, is commonly used for optimal body weight loss.
Paul J. Arciero, Karen M. Arciero, Michelle Poe, Alex E. Mohr, Stephen J. Ives, Autumn Arciero, Molly Boyce, Jin Zhang, Melissa Haas, Emma Valdez, Delaney Corbet, Kaitlyn Judd, Annika Smith, Olivia Furlong, Marley Wahler, Eric Gumpricht   +15 more
doaj   +1 more source

Metabolism of Butoxyethanol in excised human skin in vitro [PDF]

, 2008
Glycol ethers are widely used in industrial and household applications because their chemical and physical properties make them versatile solvents, miscible with both water and organic media.
Traynor, M.J., Wilkinson, S.C., Williams, F.M.   +2 more
core   +1 more source

Cystatin C is associated with adverse COVID-19 outcomes in diverse populations

iScience, 2022
Summary: COVID-19 has highly variable clinical courses. The search for prognostic host factors for COVID-19 outcome is a priority. We performed logistic regression for ICU admission against a polygenic score (PGS) for Cystatin C (CyC) production in ...
Sam O. Kleeman, Mattia Cordioli, Paul R.H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah V. Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, Tobias Janowitz   +13 more
doaj   +1 more source

Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]

, 2019
Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska, De Clerck, Laura, Deforce, Dieter, Devreese, Mathias, Govaert, Elisabeth, Millecam, Joske, Schelstraete, Wim, Van Bocxlaer, Jan   +7 more
core   +1 more source

Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine

Metabolites, 2023
Recent advancements in omics technologies have generated a wealth of biological data. Integrating these data within mathematical models is essential to fully leverage their potential.
Partho Sen, Matej Orešič
doaj   +1 more source

Androgen Metabolism in Human Skin [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1971
ABSTRACT Androgen metabolism has been studied in fetal and adult skin with definitive identification of radiometabolites and the use of a computerized technique for their quantitative determination. After infusion of testosterone-4-14C to previable fetuses, from the 12th to 22nd week of gestation, there was a higher proportion of untransformed ...
CARLO FLAMIGNI, WILLIAM P. COLLINS, EVAGORAS N. KOULLAPIS, IAN CRAFT, CHRISTOPHER J. DEWHURST, IAN F. SOMMERVILLE   +5 more
openaire   +3 more sources

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. [PDF]

, 2016
Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer.
Anderton, Brittany, Balakrishnan, Sanjeev, Camarda, Roman, Eyob, Henok, Goga, Andrei, Kajimura, Shingo, Kohnz, Rebecca A, Krings, Gregor, Mahieu, Celine, Nomura, Daniel K, Tward, Aaron, Zhou, Alicia Y   +11 more
core   +1 more source

Metabolic Profiling of Human Eosinophils [PDF]

Frontiers in Immunology, 2018
Immune cells face constant changes in their microenvironment, which requires rapid metabolic adaptation. In contrast to neutrophils, which are known to rely near exclusively on glycolysis, the metabolic profile of human eosinophils has not been characterized.
Porter, Linsey, Toepfner, Nicole, Bashant, Kathleen R, Guck, Jochen, Ashcroft, Margaret, Farahi, Neda, Chilvers, Edwin R   +6 more
openaire   +7 more sources